2-N-ACETYL-1',2'-DI-O-ACETYL-6-BIOPTERIN

Base Information

• Chemical Name: 2-N-ACETYL-1',2'-DI-O-ACETYL-6-BIOPTERIN
• CAS No.: 81827-31-8
• Molecular Formula: C15H17N5O6
• Molecular Weight: 363.33
• Mol file: 81827-31-8.mol

Synonyms:Acetamide, N-[6-[1,2-bis(acetyloxy)propyl]-1,4-dihydro-4-oxo-2-pteridinyl]-, [S-(R*,S*)]-;N2,1',2'-O-Triacetyl-L-biopterin;Triacetyl-L-erythro-biopterin;

Chemical Property of 2-N-ACETYL-1',2'-DI-O-ACETYL-6-BIOPTERIN

Chemical Property:

• Melting Point: 155 °C
• Refractive Index: 1.65
• PSA: 153.23000
• Density: 1.519 g/cm³
• LogP: 0.30030
• Solubility.: Acetone, Acetonitrile, Ethanol, hot Ethyl Acetate, Methanol

Purity/Quality:

98% ^*data from raw suppliers

2-N-Acetyl-1’,2’-di-O-acetyl-6-biopterin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of a variety of pharmaceutical agents

Technology Process of 2-N-ACETYL-1',2'-DI-O-ACETYL-6-BIOPTERIN

There total 4 articles about 2-N-ACETYL-1',2'-DI-O-ACETYL-6-BIOPTERIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + 1',2'-O-diacetyl-L-biopterin (62933-57-7) → 2-N-acetyl-1',2'-di-O-acetyl-L-erythro-biopterin (81827-31-8)

Guidance literature:

With pyridine; at 100 ℃; for 4h;

DOI:10.1021/jo961426s

Reference yield:

2,3-cyclohexylidene-5-deoxy-L-ribose (38279-72-0) → 2-N-acetyl-1',2'-di-O-acetyl-L-erythro-biopterin (81827-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 14 g / 0.2 N HCl / dioxane; H₂O / 10 h / 70 °C

2: acetic acid / methanol / 2 h / Ambient temperature

With hydrogenchloride; acetic acid; In 1,4-dioxane; methanol; water;

Reference yield:

5-deoxy-L-ribose (93978-94-0,93978-95-1,113421-68-4,113421-69-5,113421-70-8,113421-71-9,113421-72-0,113421-73-1,947605-23-4) → 2-N-acetyl-1',2'-di-O-acetyl-L-erythro-biopterin (81827-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / 2 h / Ambient temperature

With acetic acid; In methanol;

upstream raw materials:

acetic anhydride

2,4,5-triamino-6-hydroxypyrimidine sulfate

5-deoxy-L-ribose phenylhydrazone

1',2'-O-diacetyl-L-biopterin

Downstream raw materials:

biopterin

Refernces

• 1、 Mori, Kenji,Kikuchi, Haruhiko. "A New Synthesis of (-)-Biopterin Employing 5-Deoxy-L-ribose as a Key Intermediate". . p. 1267 - 1270. Retrieved 2007/10/02.