C₁₈H₁₆⁽²⁾H₂N₂

Base Information

• Chemical Name: C₁₈H₁₆⁽²⁾H₂N₂
• CAS No.: 1361111-17-2
• Molecular Formula: C₁₈H₁₈N₂
• Molecular Weight: 264.338
• Mol file: 1361111-17-2.mol

Synonyms:C₁₈H₁₆⁽²⁾H₂N₂

Chemical Property of C₁₈H₁₆⁽²⁾H₂N₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₈H₁₆⁽²⁾H₂N₂

There total 6 articles about C₁₈H₁₆⁽²⁾H₂N₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[D3]acetonitrile (2206-26-0) + N-((E)-3-phenylallylidene)benzylamine (60293-41-6) → C18H16(2)H2N2 (1361111-17-2)

Guidance literature:

[D₃]acetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

N-((E)-3-phenylallylidene)benzylamine; In tetrahydrofuran; at -78 ℃; for 4h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; Saturated solution;

DOI:10.1016/j.tetlet.2012.01.004

Reference yield:

methyl 3-(benzylamino)-2,2-dideutero-3-(4-bromophenyl)propanoate (1361110-35-1) → C18H16(2)H2N2 (1361111-17-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; ammonium formate

2.1: potassium carbonate / methanol / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 4 h / -78 °C / Inert atmosphere

3.3: Saturated solution

With palladium on activated charcoal; ammonium formate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2012.01.004

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → C18H16(2)H2N2 (1361111-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 °C / Inert atmosphere

2.3: Saturated solution

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2012.01.004

upstream raw materials:

(E)-3-phenylpropenal

methyl 3-(benzylamino)-2,2-dideutero-3-(4-bromophenyl)propanoate

C₁₆H₁₃⁽²⁾H₂BrN₂

[D₃]acetonitrile

Downstream raw materials:

(E)-methyl 3-(benzylamino)-2,2-dideutero-5-phenylpent-4-enoate

Refernces