Sulfameter

Base Information

• Chemical Name: Sulfameter
• CAS No.: 651-06-9
• Molecular Formula: C11H12N4O3S
• Molecular Weight: 280.307
• Hs Code.: 29350090
• European Community (EC) Number: 211-480-8
• NSC Number: 757874,683528
• UNII: 3L179F09D6
• DSSTox Substance ID: DTXSID5023613
• Nikkaji Number: J9.462E
• Wikipedia: Sulfametoxydiazine
• Wikidata: Q15410181
• NCI Thesaurus Code: C66568
• Metabolomics Workbench ID: 58723
• ChEMBL ID: CHEMBL1200359
• Mol file: 651-06-9.mol

Synonyms:Sulfameter;Sulfamethoxydiazine;Sulfamethoxydine;Sulfametin;Sulfametorinum;Sulfametoxidine;Sulfametoxydiazine;Sulphamethoxydiazine

Chemical Property of Sulfameter

Chemical Property:

• Appearance/Colour: Crystalline Solid
• Melting Point: 214-216°C
• Refractive Index: 1.6200 (estimate)
• Boiling Point: 539.4 °C at 760 mmHg
• PKA: pKa 7.02 (Uncertain)
• Flash Point: 280 °C
• PSA: 115.58000
• Density: 1.465 g/cm³
• LogP: 2.60320
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Sparingly)
• Water Solubility.: 0.47g/L(30 oC)
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 280.06301143
• Heavy Atom Count: 19
• Complexity: 368

Purity/Quality:

99% ^*data from raw suppliers

Sulfameter ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
• Uses: Sulfameter is an antibacterial. An antibacterial Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.
• Therapeutic Function: Antibacterial

Technology Process of Sulfameter

There total 1 articles about Sulfameter which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ sulfameter (651-06-9)

Guidance literature:

2-Methansulfonyl-5-methoxy-pyrimidin (V), Sulfanilamid, K2CO3, ca. 150grad;

Reference yield: 100.0%

sulfameter (651-06-9) + 2,3-isopropylidene-glyceraldehyde (15186-48-8) → 4-{[1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amino}-N-(5-methoxy-pyrimidin-2-yl)-benzenesulfonamide

Guidance literature:

With toluene-4-sulfonic acid; In dimethyl sulfoxide; toluene;

DOI:10.1080/00397910008087410

Reference yield: 100.0%

sulfameter (651-06-9) + (d,l) isopropylidene glyceraldehyde (5736-03-8) → 4-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methylene]amino}-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide

Guidance literature:

With toluene-4-sulfonic acid; In dimethyl sulfoxide; toluene;

DOI:10.1080/00397910008087410

Downstream raw materials:

2-Hydroxy-5-methoxypyrimidin

sulfanilamide

5-methoxypyrimidin-2-amine

4-aminobenzene sulfonic acid