Technology Process of N-(cyclohexylmethyl)-4,6-dimethyl-1H-indole-2-carboxamide
There total 3 articles about N-(cyclohexylmethyl)-4,6-dimethyl-1H-indole-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,6-dimethyl-1H-indole-2-carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
cyclohexylmethylamine;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/jm4003878
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: p-toluenesulfonic acid monohydrate / benzene / Reflux; Dean-Stark
2.1: lithium hydroxide; ethanol / Reflux
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
3.2: 20 °C
With
ethanol; p-toluenesulfonic acid monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
dichloromethane; benzene;
1.1: |Fischer Indole Synthesis;
DOI:10.1021/jm4003878
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide; ethanol / Reflux
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
2.2: 20 °C
With
ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
dichloromethane;
DOI:10.1021/jm4003878