(R)-α-bromo-2-chlorophenylacetic acid

Base Information

• Chemical Name: (R)-α-bromo-2-chlorophenylacetic acid
• CAS No.: 256398-61-5
• Molecular Formula: C₈H₆BrClO₂
• Molecular Weight: 249.491
• Mol file: 256398-61-5.mol

Synonyms:(R)-α-bromo-2-chlorophenylacetic acid

Chemical Property of (R)-α-bromo-2-chlorophenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-α-bromo-2-chlorophenylacetic acid

There total 1 articles about (R)-α-bromo-2-chlorophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-bromo-2-chlorophenyl acetic acid (29270-30-2,141109-25-3) → (S)-(+)-2-bromo-2-(2-chlorophenyl)acetic acid (141109-25-3) + (R)-α-bromo-2-chlorophenylacetic acid (256398-61-5,141109-25-3)

Guidance literature:

α-bromo-2-chlorophenyl acetic acid; With D-(+)-O,O'-dibenzoyltartaric acid; copper diacetate; In acetonitrile; at 40 ℃; for 168h;

With hydrogenchloride; In toluene; at 50 ℃; Title compound not separated from byproducts;

DOI:10.1039/b510170k

Reference yield:

(R)-α-bromo-2-chlorophenylacetic acid (256398-61-5,141109-25-3) + copper(II) acetate monohydrate (6046-93-1) + (+)-dibenzoyl-D-tartaric acid monohydrate (80822-15-7) + acetonitrile (75-05-8,26809-02-9) → [Cu2(D-O,O'-dibenzoyltartrate)((R)-α-bromo-2-chlorophenylacetate)(OAc)(H2O)2]*1.5MeCN

Guidance literature:

In acetonitrile; to soln. D-O,O'-dibenzoyltartaric acid*H2O and α-halocarboxylic acid in MeCN at 40°C was added Cu(OAc)2*H2O, mixt. was stirred for 30 min;

DOI:10.1039/b510170k

Reference yield:

(R)-α-bromo-2-chlorophenylacetic acid (256398-61-5,141109-25-3) + copper(II) acetate monohydrate (6046-93-1) + (-)-O,O′-dibenzoyl-L-tartaric acid monohydrate (62708-56-9) + acetonitrile (75-05-8,26809-02-9) → [Cu2(L-O,O'-dibenzoyltartrate)((S)-α-bromo-2-chlorophenylacetate)(OAc)(H2O)2]*1.5MeCN + [Cu2(L-O,O'-dibenzoyltartrate)((R)-α-bromo-2-chlorophenylacetate)(OAc)(H2O)2]*1.5MeCN

Guidance literature:

In acetonitrile; to soln. L-O,O'-dibenzoyltartaric acid*H2O and α-halocarboxylic acid in MeCN at 40°C was added Cu(OAc)2*H2O, mixt. was stirred for 2 days;

DOI:10.1039/b510170k

upstream raw materials:

α-bromo-2-chlorophenyl acetic acid

Refernces

• 1、 He, Bao-Jiang,Yin, Chuan-Qi,Li, Shi-Rong,Bai, Zheng-Wu. "Synthesis of dendrimer-type chiral stationary phases based on the selector of (1S,2R)-(+)-2-amino-1,2-diphenylethanol derivate and their enantioseparation evaluation by HPLC". experimental part. p. 69 - 76. Retrieved 2010/09/09.