3-(3-PHENOXY-PHENYL)-PROPIONALDEHYDE

Base Information

• Chemical Name: 3-(3-PHENOXY-PHENYL)-PROPIONALDEHYDE
• CAS No.: 122801-83-6
• Molecular Formula: C15H14 O2
• Molecular Weight: 226.27046
• Mol file: 122801-83-6.mol

Synonyms:3-(3-PHENOXY-PHENYL)-PROPIONALDEHYDE

Chemical Property of 3-(3-PHENOXY-PHENYL)-PROPIONALDEHYDE

Chemical Property:

• Vapor Pressure: 8.68E-05mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 340.3°C at 760 mmHg
• Flash Point: 146.6°C
• PSA: 26.30000
• Density: 1.094g/cm³
• LogP: 3.61040

Purity/Quality:

97% ^*data from raw suppliers

3-(3-PHENOXY-PHENYL)-PROPIONALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-PHENOXY-PHENYL)-PROPIONALDEHYDE

There total 7 articles about 3-(3-PHENOXY-PHENYL)-PROPIONALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + 3-ethenylphenyl phenyl ether (63444-54-2) → 2-(3-phenoxy-phenyl)-propionaldehyde (59908-87-1) + 3-(3-phenoxyphenyl)propanal (122801-83-6)

Guidance literature:

With di(rhodium)tetracarbonyl dichloride; hydrogen; 1,2,5-triphenyl-1H-phosphole; triethylamine; In toluene; at 25 ℃; for 6h; under 15001.2 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00283a008

Reference yield:

3-(3-phenoxyphenyl)propan-1-ol (106797-69-7) → 3-(3-phenoxyphenyl)propanal (122801-83-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01570

Reference yield:

1-(m-phenoxyphenyl)-1-chloroethane (80379-89-1) → 3-(3-phenoxyphenyl)propanal (122801-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide, 3-tert-butyl catechol, tetrabutylammonium bromide / 1 h / 120 °C

2: H₂, 2, 1,2,5-triphenylphosphole, triethylamine / toluene / 6 h / 25 °C / 15001.2 Torr

With potassium hydroxide; di(rhodium)tetracarbonyl dichloride; 3-tert-butylbenzene-1,2-diol; tetrabutylammomium bromide; hydrogen; 1,2,5-triphenyl-1H-phosphole; triethylamine; In toluene;

DOI:10.1021/jo00283a008

upstream raw materials:

carbon monoxide

3-ethenylphenyl phenyl ether

1-(m-phenoxyphenyl)-1-chloroethane

3-hydroxy-trans-cinnamic acid

Refernces

• 1、 Neibecker, Denis,Reau, Regis,Lecolier, Serge. "Synthesis of 2-Arylpropionaldehydes through Hydroformylation". . p. 5208 - 5210. Retrieved 2007/10/02.