5-(benzyloxy)-2,4-dichloropyrimidine

Base Information

• Chemical Name: 5-(benzyloxy)-2,4-dichloropyrimidine
• CAS No.: 91183-17-4
• Molecular Formula: C11H8Cl2N2O
• Molecular Weight: 255.103
• Hs Code.: 2933599090
• Mol file: 91183-17-4.mol

Synonyms:2,4-dichloro-5-phenylmethoxypyrimidine

Chemical Property of 5-(benzyloxy)-2,4-dichloropyrimidine

Chemical Property:

• Boiling Point: 381.6±27.0 °C(Predicted)
• PKA: -2.70±0.29(Predicted)
• PSA: 35.01000
• Density: 1.382
• LogP: 3.36240
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-(Benzyloxy)-2,4-dichloropyrimidine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(benzyloxy)-2,4-dichloropyrimidine

There total 4 articles about 5-(benzyloxy)-2,4-dichloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.7%

C11H10N2O3 (92016-70-1) → 5-benzyloxy-2,4-dichloro-pyrimidine (91183-17-4)

Guidance literature:

With trichlorophosphate; for 5h; Inert atmosphere; Reflux;

Reference yield:

ethyl benzyloxyacetate (32122-09-1) → 5-benzyloxy-2,4-dichloro-pyrimidine (91183-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium / toluene / 20 - 30 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: trichlorophosphate / 5 h / Inert atmosphere; Reflux

With sodium; trichlorophosphate; In toluene;

Reference yield:

benzyloxyacetic acid (30379-55-6) → 5-benzyloxy-2,4-dichloro-pyrimidine (91183-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / Inert atmosphere; Reflux

2.1: sodium / toluene / 20 - 30 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: trichlorophosphate / 5 h / Inert atmosphere; Reflux

With sulfuric acid; sodium; trichlorophosphate; In toluene;

upstream raw materials:

benzyloxyacetic acid

ethyl benzyloxyacetate

C₁₁H₁₀N₂O₃

Downstream raw materials:

C₁₅H₁₄ClN₅O

C₂₂H₂₁N₇O₃

C₂₂H₂₃N₇O

Refernces

• 1、 -. "4-SUBSTITUTED-(3-SUBSTITUTED-1H-PYRAZOLE-5-AMINO)-PYRIMIDINE DERIVATIVES HAVING ACTIVITY OF INHIBITING PROTEIN KINASE AND USE THEREOF". . . Retrieved 2015/01/07.