trans-1-hydroxy-2,7-diaminomitosene

Base Information

• Chemical Name: trans-1-hydroxy-2,7-diaminomitosene
• CAS No.: 99745-88-7
• Molecular Formula: C₁₄H₁₆N₄O₅
• Molecular Weight: 320.305
• Mol file: 99745-88-7.mol

Synonyms:

Chemical Property of trans-1-hydroxy-2,7-diaminomitosene

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

trans-1-Hydroxy-2,7-diaminoMitosene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: trans-1-Hydroxy-2,7-diamino Mitosene is derived from Mitomycin C (M371900), which is an antitumor antibiotic. It is antineoplastic.

Technology Process of trans-1-hydroxy-2,7-diaminomitosene

There total 16 articles about trans-1-hydroxy-2,7-diaminomitosene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

mitomycin C (50-07-7) → cis-1-hydroxy-2-acetamido-7-aminomitosene (54911-22-7) + trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 2,7-Diaminomitosene (92695-32-4)

Guidance literature:

With Tris-HOAc-buffer pH 5.50; 4-methoxyphenylhydrazine hydrochloride; In water; for 48h; Mechanism; Ambient temperature; other substrates, also with D₂O;

DOI:10.1021/jo00032a037

Reference yield: 30.0%

mitomycin C (50-07-7) → trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 7-aminoaziridinomitosene (103422-25-9)

Guidance literature:

In methanol; for 0.0833333h; at -1.00 V, Pt electrode vs. SCE, supporting electrolyte: 0.1 M NaClO₄;

DOI:10.1021/jo00015a016

Reference yield: 28.8%

mitomycin C (50-07-7) → trans-1-hydroxy-2,7-diaminomitosene (99745-88-7,78655-54-6) + 2β,7-Diamino-1β-hydroxymitosene (98462-75-0,78655-54-6) + 10-decarbamoyl-2,7-diaminomitosene (102587-27-9) + 2,7-Diaminomitosene (92695-32-4) + trans-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene (92761-61-0) + cis-10-decarbamoyl-1,10-dihydroxy-2,7-diaminomitosene (92761-60-9)

Guidance literature:

With chromium(II) perchlorate; 2-[Bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol Hydrochloride; In water; for 0.5h; Product distribution; Mechanism; Ambient temperature; other solvents, var. pH; other reaction partners;

upstream raw materials:

mitomycin C

7-aminoaziridinomitosene

2',3'-isopropylideneguanosine

N,N-Dimethylhydrazine

Refernces

• 1、 Palom, Jolanda,Lipman, Roselyn,Musser, Steven M.,Tomasz, Maria. "A mitomycin-N6-deoxyadenosine adduct isolated from DNA.". . p. 203 - 210. Retrieved 2007/10/03.
• 2、 Schiltz, Pascal,Kohn, Harold. "Studies on the reactivity of reductively activated mitomycin C". . p. 10510 - 10518. Retrieved 2007/10/02.