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SB 202190

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Name

SB 202190

EINECS N/A
CAS No. 152121-30-7 Density 1.311 g/cm3
PSA 61.80000 LogP 4.65040
Solubility DMSO: 30 mg/mL Melting Point 240-243℃
Formula C20H14FN3O Boiling Point 565.705 °C at 760 mmHg
Molecular Weight 331.349 Flash Point 295.928 °C
Transport Information N/A Appearance pale yellow
Safety 26-36/37 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 152121-30-7 (Phenol,4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-) Hazard Symbols IrritantXi
Synonyms

C20H14FN3O;4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole;

Article Data 2

SB 202190 Specification

The IUPAC name of SB 202190 is 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one. With the CAS registry number 152121-30-7, it is also named as Phenol,4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-. The product's classification codes are Enzyme Inhibitors; Protein Kinase Inhibitors, and the other registry number is 194615-33-3. In addition, this chemical should be stored at 2-8 °C. And its color is pale yellow. Furthermore, it is potent and cell-permeable inhibitor of p38 MAP kinase. And it is also available as part of the MAPK Inhibitor TocrisetTM.

The other characteristics of SB 202190 can be summarized as: (1)ACD/LogP: 2.93; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3; (4)ACD/LogD (pH 7.4): 3; (5)ACD/BCF (pH 5.5): 125; (6)ACD/BCF (pH 7.4): 135; (7)ACD/KOC (pH 5.5): 1068; (8)ACD/KOC (pH 7.4): 1158; (9)H bond acceptors: 4; (10)H bond donors: 2; (11)Freely Rotating Bonds: 4; (12)Polar Surface Area: 61.8 Å2; (13)Index of Refraction: 1.653; (14)Molar Refractivity: 92.52 cm3; (15)Molar Volume: 252.697 cm3; (16)Polarizability: 36.678×10-24cm3; (17)Surface Tension: 58.008 dyne/cm; (18)Density: 1.311 g/cm3; (19)Flash Point: 295.928 °C; (20)Solubility DMSO: 30 mg/mL; (21)Enthalpy of Vaporization: 88.124 kJ/mol; (22)Boiling Point: 565.705 °C at 760 mmHg; (23)Vapour Pressure: 0 mmHg at 25 °C.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing and gloves when use it. Moreover, in case of contact with eyes, please rinse immediately with plenty of water and seek medical advice.

People can use the following data to convert to the molecule structure.
(1)SMILES:Fc1ccc(cc1)c2nc(nc2c3ccncc3)c4ccc(O)cc4
(2)InChI:InChI=1/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
(3)InChIKey:QHKYPYXTTXKZST-UHFFFAOYAR
(4)Std. InChI:InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
(5)Std. InChIKey:QHKYPYXTTXKZST-UHFFFAOYSA-N

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