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Name	Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy-2',4',5',7'-tetraiodo-	EINECS	240-046-0
CAS No.	15905-32-5	Density	2.93 g/cm³
PSA	75.99000	LogP	6.08420
Solubility	spirit: soluble	Melting Point	303 °C (dec.)(lit.)
Formula	C20H8 I4 O5	Boiling Point	628.3 °C at 760 mmHg
Molecular Weight	835.899	Flash Point	333.8 °C
Transport Information	N/A	Appearance	powder
Safety	22-24/25	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Fluorescein,2',4',5',7'-tetraiodo- (8CI); 2',4',5',7'-Tetraiodofluorescein;3',6'-Dihydroxy-2',4',5',7'-tetraiodospiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one;C.I. 45430:2; C.I. Solvent Red 140; Erythrosin J; Erythrosine J; Erythrosineacid; Iodeosin; NSC 328781; Solvent Red 140; Tetraiodofluorescein	Article Data	17

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy-2',4',5',7'-tetraiodo- Synthetic route

: 2321-07-5
fluorescein

A: 56254-06-9
2',4',5'-triiodofluorescein

B: 15905-32-5
erythrosine B

Conditions

Conditions	Yield
With Oxone; sodium iodide at 200℃; for 12h;	A 70% B 30%

: 64-17-5
ethanol

: 2321-07-5
fluorescein

: 15905-32-5
erythrosine B

Conditions

Conditions	Yield
With pyridine; iodine; silver nitrate

: 2321-07-5
fluorescein

: 15905-32-5
erythrosine B

Conditions

Conditions	Yield
With iodine Behandeln mit Eisessig;
With sodium hydroxide; iodine; acetic acid
With dihydrogen peroxide; sodium iodide In ethanol at 20℃; for 5h; Autoclave; Large scale;

: Erythrosin

: 15905-32-5
erythrosine B

Conditions

Conditions	Yield
With oxygen Irradiation; photo-bleaching in some polymer-films: permeability of O2, glass-transition-temp., rel. index of polarity, quantum yield of bleaching, influence of O2;

: 75-36-5
acetyl chloride

: 15905-32-5
erythrosine B

: 77084-69-6
erythrosin B diacetate

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane for 1h;	32%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 15905-32-5
erythrosine B

: erythrosin n-hydroxysulfosuccinimide

Conditions

Conditions	Yield
dicyclohexyl-carbodiimide In DMF (N,N-dimethyl-formamide) at 4 - 20℃;

polycaprolactone diol terminated with 3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid: polycaprolactone diol terminated with 3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid

: 15905-32-5
erythrosine B

trifunctional lactate polymer with erythrosin: trifunctional lactate polymer with erythrosin

Conditions

Conditions	Yield
dicyclohexyl-carbodiimide In benzene at 0℃; for 72h;

polyethylene glycol 1000: polyethylene glycol 1000

: 15905-32-5
erythrosine B

polyethylene glycol; erythrosin-terminated: polyethylene glycol; erythrosin-terminated

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In DMF (N,N-dimethyl-formamide) at 0℃; for 16h;

: 15905-32-5
erythrosine B

: 16423-68-0, 63467-67-4
2',4',5',7'-tetraiodofluorescein disodium salt

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 4.5h; Autoclave; Large scale;	7.9 kg

: 15905-32-5
erythrosine B

: 5188-07-8
sodium thiomethoxide

: C21H13I3O5S

Conditions

Conditions	Yield
Stage #1: erythrosine B; sodium thiomethoxide With acetic anhydride Stage #2: With tetrakis(triphenylphosphine) palladium(0) Further stages;

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