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The Ticarcillin disodium salt, with the CAS registry number 4697-14-7, is also known as N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-3-thiophenemalonamic acid disodium salt. This chemical's molecular formula is C15H14N2Na2O6S2 and molecular weight is 428.39. What's more, its systematic name is Disodium (2S,5R,6R)-6-{[carboxylato(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. Its classification codes are: (1)Antibacterial; (2)Drug / Therapeutic Agent; (3)Reproductive Effect. This chemical is an antibiotic derived from penicillin similar to carbenicillin in action. It can be used for the treatment of clinical sepsis, urinary tract infections, respiratory infections and biliary tract infections, and also used in patients with leukemia and malignant secondary infection. It is also valid with typhoid fever.
Physical properties of Ticarcillin disodium salt are: (1)#H bond acceptors: 8; (2)#H bond donors: 3; (3)#Freely Rotating Bonds: 5; (4)Polar Surface Area: 174.42 Å2.
When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. It may cause sensitisation by inhalation and skin contact. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing and gloves.
You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].[Na+].O=C([O-])[C@@H]2N3C(=O)[C@@H](NC(=O)C(c1ccsc1)C([O-])=O)[C@H]3SC2(C)C
(2)Std. InChI: InChI=1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7?,8-,9+,12-;;/m1../s1
(3)Std. InChIKey: ZBBCUBMBMZNEME-UBXQQCHXSA-L
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | > 4gm/kg (4000mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
dog | LD50 | subcutaneous | 7gm/kg (7000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. | |
mouse | LD50 | intraperitoneal | 7800mg/kg (7800mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
mouse | LD50 | intravenous | 5200mg/kg (5200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
mouse | LD50 | oral | > 16gm/kg (16000mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
mouse | LD50 | subcutaneous | 10700mg/kg (10700mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. | |
rabbit | LD50 | intravenous | > 8gm/kg (8000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. | |
rabbit | LD50 | subcutaneous | > 11gm/kg (11000mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
rat | LD50 | intraperitoneal | 7200mg/kg (7200mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
rat | LD50 | intravenous | 5350mg/kg (5350mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
rat | LD50 | oral | 16gm/kg (16000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |
rat | LD50 | subcutaneous | 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 556, 1978. |