Bioavailability

Synthesis In vitro Mass spectrometry Derivatives Stereochemistry Structural features High-performance liquid chromatography (HPLC) in vivo Structure-Activity Relationship (SAR) Analysis Chemical Synthesis Structure-Activity Relationship (SAR) Studies In Vivo Studies Mechanism of Action Substituent Groups Design Structure-Activity Relationship (SAR) Pharmacokinetics Toxicity Coumarin Synergistic Effects Cell-Based Assays Ring Modifications Antioxidant Properties Selectivity and Toxicity Optimization of Pharmacophore Drug Delivery Systems Preclinical and Clinical Testing Combination Therapy Compound Screening Statistical Analysis Oxidative Stress Interaction with Enzymes Specific Lignan Structure Dosage Conjugated Systems Cell Line Specificity Experimental Design Indole ring Fluorobenzyl group Hydroxy groups 2-hydroxy-4-oxobut-2-enoic acid moiety Binding site interactions Insulin Sensitivity Synthetic Efficacy Glucose tolerance test Prodrug Nonpeptide renin inhibitors Intraduodenal Dog model