Preclinical and Clinical Testing

Medicinal chemistry Characterization Optimization pharmacokinetic properties Structural characterization X-ray crystallography Structure-Activity Relationship (SAR) Analysis Retrosynthetic analysis Chemical Synthesis Biological Assays Structure-Activity Relationship (SAR) Studies Workup and Purification Literature Review Lead Optimization Mechanism of Action Hit Identification Toxicity Assessment Formulation Development Regulatory Approval Analytical Characterization Market Launch Formulation Toxicity and Safety Evaluation Scale-Up Production Pharmacokinetics and Pharmacodynamics Target Identification and Validation Post-Market Surveillance Discovery In Vitro and In Vivo Assays Selectivity and Toxicity Bioavailability Optimization of Pharmacophore Drug Delivery Systems Combination Therapy Data Analysis and Publication Precursor Synthesis Telescoped Double Amidation Define the research objectives Choose the prodrug strategy Water Solubility Testing Efficacy Evaluation Production and Commercialization Synthesis Planning Pharmacokinetics and Toxicology Studies Design of Phenylisoxazole Derivatives Macrocycle Design Toxicity and Safety Studies Molecular Docking and Computational Modeling