Deprotection of Hydroxyl Groups

Characterization Biological testing Purification Starting Material Final steps Purification and Isolation Glycosidic Bond Formation Protection of Hydroxyl Groups Protection of N-Acetylneuraminic Acid (Neu5Ac) Bromination at C-2 Position Activation of the 2β-Bromo Group Deprotection and Isolation Introduction of the Amino Group Selective Deoxygenation O-Methylation Selectively Oxidize the Secondary Alcohol Selective Methylation Introduction of the 5-Substituent Protection of Nucleoside Hydroxyl Groups Introduction of the First Substituent (at 5th position) Protection of the 5th Position Substituent Introduction of the Second Substituent (at 6th position) Formation of Ascorbate-6-Phosphate