What is Protection of Nucleoside Hydroxyl Groups

Protection of Nucleoside Hydroxyl Groups

To start the synthesis, the 2'- and 3'-hydroxyl groups on the ribose sugar of uridine are usually protected to prevent unwanted reactions.

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Deprotection of Hydroxyl Groups Introduction of the 5-Substituent Introduction of the First Substituent (at 5th position) Protection of the 5th Position Substituent Introduction of the Second Substituent (at 6th position)

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