Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Trityl Losartan
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

Trityl Losartan

 EINECS 412-420-5
CAS No. 133909-99-6 Density 1.22 g/cm3
PSA 81.65000 LogP 8.58040
Solubility N/A Melting Point N/A
Formula C41H37ClN6O Boiling Point 856.6 °C at 760 mmHg
Molecular Weight 665.237 Flash Point 471.9 °C
Transport Information N/A Appearance N/A
Safety 61 Risk Codes 53
Molecular Structure Molecular Structure of 133909-99-6 (Trityl losartan) Hazard Symbols N/A
Synonyms

2-Butyl-4-chloro-1-[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]-1H-imidazole-5-methanol;(2-Butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol;

Article Data 16

Trityl Losartan Synthetic route

83857-96-9

2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

133051-88-4

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde; N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole With potassium carbonate In N,N-dimethyl-formamide at 20 - 22℃; for 3h;
Stage #2: With sodium tetrahydroborate In water; N,N-dimethyl-formamide at 48 - 52℃; for 3.08333h;		99.2%
With potassium carbonate In N,N-dimethyl acetamide
With potassium carbonate In N,N-dimethyl acetamide
76-83-5

trityl chloride

124750-99-8

cozaar

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;91%
79047-41-9

2-n-butyl-4-chloro-5-hydroxymethylimidazole

133051-88-4

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h;80%
109-69-3

n-Butyl chloride

133910-00-6

2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
With sodium borohydrid In water; ethyl acetate72%
With sodium borohydrid In water; ethyl acetate72%
133910-00-6

2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde

99281-96-6

3-<3,4-bis(benzyloxy)phenyl>-1-aminopropane

A

1370339-88-0

[3-(3,4-bis-benzyloxy-phenyl)propyl](2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl)amine

B

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
Stage #1: 2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde; 3-<3,4-bis(benzyloxy)phenyl>-1-aminopropane With magnesium sulfate In dichloromethane at 20℃; for 17h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In methanol; dichloromethane at 20℃; for 4h; Inert atmosphere;		A 34%
B 40%
109-69-3

n-Butyl chloride

83857-96-9

2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

143722-28-5

5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
With sodium borohydrid In water; ethyl acetate; acetone28%
With sodium borohydrid In water; ethyl acetate; acetone28%
79047-41-9

2-n-butyl-4-chloro-5-hydroxymethylimidazole

133051-88-4

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

A

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

B

{2-Butyl-5-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-imidazol-4-yl}-methanol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Product distribution; Ambient temperature; various ratios of reagents;
With potassium carbonate In N,N-dimethyl-formamide Ambient temperature;
76-83-5

trityl chloride

114772-55-3

2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
Yield given. Multistep reaction;
133910-00-6

2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
With sodium tetrahydroborate In dichloromethane at 25℃; for 24h; Yield given;
87268-78-8

2-trityl-5-phenyl-2H-tetrazole

151012-31-6

2-n-Butyl-4-chloro-1-(4-bromobenzyl)-1H-imidazole-5-methanol

133909-99-6

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions
ConditionsYield
Yield given. Multistep reaction;

Trityl Losartan Specification

The Trityl Losartan with CAS registry number of 133909-99-6 is also known as 2-Butyl-4-chloro-1-[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]-1H-imidazole-5-methanol. The systematic name is (2-Butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol. Its EINECS registry number is 412-420-5. In addition, the formula is C41H37ClN6O and the molecular weight is 665.23.

Physical properties about Trityl Losartan are: (1)ACD/LogP: 8.45; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 8.42; (4)ACD/LogD (pH 7.4): 8.45; (5)ACD/BCF (pH 5.5): 1000000; (6)ACD/BCF (pH 7.4): 1000000; (7)ACD/KOC (pH 5.5): 872888.94; (8)ACD/KOC (pH 7.4): 937635.38; (9)#H bond acceptors: 7; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 13; (12)Index of Refraction: 1.656; (13)Molar Refractivity: 199.59 cm3; (14)Molar Volume: 542.9 cm3; (15)Surface Tension: 49.8 dyne/cm; (16)Density: 1.22 g/cm3; (17)Flash Point: 471.9 °C; (18)Enthalpy of Vaporization: 130.44 kJ/mol; (19)Boiling Point: 856.6 °C at 760 mmHg; (20)Vapour Pressure: 2.96E-31 mmHg at 25 °C.

When you are using this chemical, please be cautious about it. As a chemical, it may cause long-term adverse effects in the aquatic environment. During using it, avoid release to the environment refer to special instructions/safety data sheet.

You can still convert the following datas into molecular structure:
1. SMILES: Clc1nc(n(c1CO)Cc2ccc(cc2)c7ccccc7c3nn(nn3)C(c4ccccc4)(c5ccccc5)c6ccccc6)CCCC
2. InChI: InChI=1/C41H37ClN6O/c1-2-3-23-38-43-39(42)37(29-49)47(38)28-30-24-26-31(27-25-30)35-21-13-14-22-36(35)40-44-46-48(45-40)41(32-15-7-4-8-16-32,33-17-9-5-10-18-33)34-19-11-6-12-20-34/h4-22,24-27,49H,2-3,23,28-29H2,1H3
3. InChIKey: QQPGGBNMTNDKEY-UHFFFAOYAZ

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 133909-99-6