Reference

Comparison of systemic and regional hemodynamic effects of a diuretic, an angiotensin II receptor antagonist, and an angiotensin-converting enzyme inhibitor in conscious renovascular hypertensive rats

Comparison of systemic and regional hemodynamic effects of a diuretic, an angiotensin II receptor antagonist, and an angiotensin-converting enzyme inhibitor in conscious renovascular hypertensive rats. Wang, Yi Xin; Gavras, Irene; Wierzba, Tomasz; Gavras, Haralambos (Hypertens. Sect., Boston City Hosp., Boston, MA, USA). J. Lab. Clin. Med., 119(3), 267-72 (English) 1992. CODEN: JLCMAK. ISSN: 0022-2143. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The present expts.Several reagents with their cas registry numbers 11128-99-7 and 124750-99-8 are used here. were designed to compare the antihypertensive action and the systemic and regional hemodynamic effects of a diuretic (furosemide), an angiotensin II (AngII) receptor blocker (Dup 753), and an angiotensin converting enzyme (ACE) inhibitor [enalapril] in conscious, two-kidney, one-clip renovascular hypertensive rats by the radioactive microsphere technique. Measurements were done 3 h after a single dose treatment. Furosemide (20 mg/kg) produced a marked diuresis and tachycardia with no change in blood pressure; in comparison with control rats, furosemide-treated rats had total peripheral vascular resistance increased by 46.55% and local vascular resistance increased in most organs, to a significant degree in the spleen, muscle, stomach, intestine, and skin. Dup 753 (20 mg/kg) and enalapril (10 mg/kg) decreased mean blood pressure by 41.89 mm Hg and 47.13 mm Hg, resp., with tachycardia only in the Dup 753 group. Total peripheral and local vascular resistance in several tissues were significantly lower in both the Dup 753 and enalapril groups than in the furosemide group. In particular, both antiangiotensin agents, in contrast to furosemide, produced significant decrease in renal vascular resistance by 42.28% and 38.81%, resp., with a tendency to increase the renal blood flow (of the intact kidney). No detectable differences were found in systemic and regional hemodynamic changes between the Dup 753 and enalapril group. Apparently, in high-renin hypertension, the hemodynamic responses to AngII blockade and ACE inhibition are similar and thus attributable to withdrawal of the action of AngII; also, acute diuresis appears to be a poor antihypertensive approach with adverse effects on the perfusion of several organs. .

Effect of the angiotensin II receptor antagonist MK 954 on the angiotensin II-induced increase in free cytosolic calcium and growth in vascular smooth muscle cells

Effect of the angiotensin II receptor antagonist MK 954 on the angiotensin II-induced increase in free cytosolic calcium and growth in vascular smooth muscle cells. Sachinidis, Agapios; Goerg, Anette; Ko, Yon; Wieczorek, Andreas J.; Duesing, Rainer; Vetter, Hans (Med. Polyclin. Bonn, Univ. Bonn, Bonn D-5300/1, Germany). J. Hypertens. 7440-70-2 and 124750-99-8 which are cas registry numbers are also used here., 9(Suppl. 6), S226-S227 (English) 1991. CODEN: JOHYD3. ISSN: 0263-6352. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) This in vitro study allows to conclude that MK 954 can inhibit angiotensin II-induced cell growth and thus may have beneficial effects in the development and regression of vascular hypertrophy, which is assocd. with the development of hypertension. .