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Trophosphamide
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Name

Trophosphamide

 EINECS N/A
CAS No. 22089-22-1 Density 1.35g/cm3
PSA 42.59000 LogP 2.77310
Solubility N/A Melting Point 47-49°C
Formula C9H18 Cl3 N2 O2 P Boiling Point 393.7°Cat760mmHg
Molecular Weight 323.587 Flash Point 191.9°C
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and POx. Risk Codes N/A
Molecular Structure Molecular Structure of 22089-22-1 (trofosfamide) Hazard Symbols N/A
Synonyms

2H-1,3,2-Oxazaphosphorine,2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-, 2-oxide (8CI);3-(2-Chloroethyl)-2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine2-oxide; Asta Z 4828; Ixoten; NSC 109723; Trifosfamide; Trilofosfamida;Trilophosphamide; Triphosphamide; Trisfosfamide; Trofosfamid; Trofosfamide; Trophosphamid;Trophosphamide; Z 4828

 

Trophosphamide Chemical Properties

IUPAC Name: N,N,2-tris(2-chloroethyl)-1-oxo-6-oxa-2-aza-1λ5-phosphacyclohexan-1-amine 
Molecular Formula: C9H18Cl3N2O2P
Molecular Weight: 323.61g/mol 
EINECS: 244-770-8
Density: 1.35g/cm3
Boiling Point: 393.7°C at 760mmHg
Flash Point: 191.9°C 
Freely Rotating Bonds: 7
Polar Surface Area: 42.59 Å2
Index of Refraction: 1.518
Molar Refractivity: 72.42 cm3
Molar Volume: 238.7 cm3
Polarizability: 28.7 ×10-24 cm3
Surface Tension: 46.1 dyne/cm
Enthalpy of Vaporization: 64.36 kJ/mol
Vapour Pressure: 2.09E-06 mmHg at 25°C 
The Cas Register Number of Trophosphamide is 22089-22-1.The chemical synonyms of Trophosphamide (CAS NO.22089-22-1) are (R)-N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide ; 2-[Bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide ; 2H-1,3,2-oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide (9CI)  ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (R)- ; N,N,3-Tris(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide ; N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-Oxide ; Trilophosphamide ; 2-(Bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide ; 2H-1,3, 2-Oxazaphosphorine, 2-[bis (2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-, 2-oxide ; 2H-1,3,2-Oxaphosphorin-2-amine, tetrahydro-N,N, 3-tris(2-chloroethyl)-, 2-oxide ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris (2-chloroethyl)tetrahydro-, 2-oxide ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (S)- ; 2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-, 2-oxide ; 3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine 2-oxide ; Cyclophosphamide, N-monochloroethyl derivative ; Ifosfamide mustard ; Ixoten ; N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide ; N,N,N'-Tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide ; N,N-3'-tris(2-chloroethyl)tetrahydro-2H-1,3,2 oxazaphosphorin-2-amine, 2-oxide ; Trifosfamide .The molecular structure of Trophosphamide (CAS NO.22089-22-1) is.

Trophosphamide Uses

 Trophosphamide (CAS NO.22089-22-1) is used as anti carcinoma drug.

Trophosphamide Toxicity Data With Reference

1.    

mma-esc 10 mmol/L

     ARTODN    Archives of Toxicology. 33 (1975),225.
2.    

sln-dmg-unr 1 mmol/L/24H

     MUREAV    Mutation Research. 33 (1975),221.
3.    

cyt-hmn:leu 100 mg/L

     HUMAA7    Humangenetik. 5 (1968),321.
4.    

cyt-rat-ipr 25 mg/kg

     HUMAA7    Humangenetik. 5 (1968),321.
5.    

mnt-mus-ipr 80 mg/kg/24H

     MUREAV    Mutation Research. 56 (1978),319.
6.    

cyt-ham-ipr 3300 µg/kg

     ARTODN    Archives of Toxicology. 38 (1977),35.
7.    

unr-hmn TDLo:50 mg/kg:BLD,KID

     SAMJAF    South African Medical Journal. 53 (1978),886.
8.    

orl-rat LD50:202 mg/kg

     MDACAP    Medicamentos de Actualidad. 13 (1977),115.
9.    

scu-rat LD50:210 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 23 (1973),922.
10.    

ivn-rat LD50:90 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 23 (1973),922.
11.    

orl-mus LD50:464 mg/kg

     MDACAP

Trophosphamide Consensus Reports

EPA Genetic Toxicology Program.

Trophosphamide Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and POx.

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