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Detail of "103890-78-4"

  • CAS Number:
  • 103890-78-4
  • Name:

  • Lacidipine

  • Molecular Structure:
  • Formula:
  • C26H33NO6
  • Molecular Weight:
  • 455.55
  • Synonyms:
  • 3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester;3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester (9CI);3,5-Pyridinedicarboxylic acid,4-[2-[3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester, (E)-;Lacimen;Lacipil;Lacirex;Midotens;Motens;
  • Density:
  • 1.127 g/cm3
  • Melting Point:
  • 174-175 °C
  • Boiling Point:
  • 558.4 °C at 760 mmHg
  • Flash Point:
  • 291.5 °C
  • Appearance:
  • White-to-off-white crystalline solid
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CAS No.103890-78-4 Lacidipine

  Package:1Mg;5Mg;10Mg...Storage:store in RT  Transportation:by air/sea  Application:Lacidipine

Supplier:SHAANXI TOP PHARM CHEMICAL CO.LTD [ China (Mainland)]

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CAS No.103890-78-4 Lacidipine

Lacidipine

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CAS No.103890-78-4 Lacidipine

Assay:99%

Supplier:Taiyuan RHF CO., ltd. [ China (Mainland)]

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CAS No.103890-78-4 Lacidipine

Assay:98%

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CAS No.103890-78-4 Lacidipine

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CAS No.103890-78-4 Lacidipine

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CAS No.103890-78-4 Lacidipine

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CAS No.103890-78-4 Lacidipine

Property: Appreance: white or pale crystal powder mp:173-176°C Quality Standard:China SDA Standard Uses: Antihypertensive

Supplier:Chedom Pharmaceutical Co.,Ltd. [ China (Mainland)]

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CAS No.103890-78-4 Lacidipine

Physical & Chemical Properties: A white to pale yellow crystalline powder. It melts at about 178°. Practically insoluble in water; freely soluble in acetone and in dichloromethane; sparingly soluble in absolute ethanol . Quality Specification Usage: Antihypertensive. Pa

Supplier:Zhejiang Shengxiao Chemicals Co., Ltd. [ China (Mainland)]

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CAS No.103890-78-4 Lacidipine

[Molecular Formula] C26H33NO6 [Molecular Weight] 455.55 [Specification] SFDA Standard. [Uses] Antihypertensive.

Supplier:Zhejiang Xinhua Pharmaceutical Co., Ltd. [ China (Mainland)]

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CAS No.103890-78-4 Lacidipine

Lacidipine

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CAS No.103890-78-4 Lacidipine

Lacidipine

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CAS No.103890-78-4 Lacidipine

Lacidipine

Supplier:Manus Aktteva Biopharma LLP [ India]

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CAS No.103890-78-4 Lacidipine

Commercial scale

Supplier:mediking Pharmaceutical Group [ China (Mainland)]

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CAS No.103890-78-4 Lacidipine

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CAS No.103890-78-4 Lacidipine

Supplier:Mulberry Chemicals Pvt. Ltd [ India]

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CAS No.103890-78-4 Lacidipine

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CAS No.103890-78-4 Lacidipine

Supplier:shanghai artis-chem co.ltd [ China (Mainland)]

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CAS No.103890-78-4 Lacidipine

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Reference

Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity
Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Van Amsterdam, Frank T. M. 103890-78-4 are also occured in this study.; Roveri, Antonella; Maiorino, Matilde; Ratti, Emiliangelo; Ursini, Fulvio (Glaxo Res. Lab., Verona, Italy). Free Radical Biol. Med., 12(3), 183-7 (English) 1992. CODEN: FRBMEH. ISSN: 0891-5849. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Lacidipine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in a series of tests that consider specific radical species. A direct quenching of several radical species could be measured. Moreover, in biol. membranes derived from rat brain tissue, lacidipine showed an activity comparable to ref. antioxidant compds. like vitamin E. .
Safety and tolerability of lacidipine
Safety and tolerability of lacidipine. Leonetti, Gastone (Ospedale S. Luca, Centro Auxologico Italiano, Milano e Cattedra di Terapia Medica, Universita di Milano, Italy). Reviews in Contemporary Pharmacotherapy, 6(1), 29-35 (English) 1995 Marius Press. CODEN: RCPHFW. ISSN: 0954-8602. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review with 28 refs. The aim of pharmacol. treatment for mild or moderate hypertension is not only a redn. of elevated blood pressure to prevent cardiovascular events and target organ damage, but also a favorable safety and tolerability profile of the administered drugs. Lacidipine is an effective antihypertensive drug of the dihyropyridine group which has no acute and chronic toxic effects in animal studies at clin. used doses; nor does it exhibit genotoxic effects or cancerogenic properties. The side effects of lacidipine are those expected for vasodilating drugs, and include headache, palpitations, tachycardia and flushing in the early phase of drug administration, and ankle edema in later stages. The vascular selectivity of lacidipine accounts for the low occurrence of constipation and the virtual absence of adverse effects at a cardiac level. The incidence of side effects in lacidipine treated patients is similar or slightly lower than that found in patients receiving nifedipine. Furthermore, the type of side effects of lacidipine are different from those assocd. with diuretics or b-blockers, but the overall incidence is not statistically different. Lacidipine does not appear to interfere with glucose, lipoprotein, or electrolyte metab. Although the pharmacokinetic profile of lacidipine is slightly different in the elderly (when compared to adult subjects) the incidence and severity of side effects is not significantly higher in the elderly. The quality of life is improved to a similar extent in elderly hypertensives during chronic treatment with lacidipine and captopril. In conclusion, lacidipine has a favorable profile of tolerability and safety in young, adult and elderly hypertensive patients.Except for chemicals metioned above, 103890-78-4 is also used. .
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