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| CAS No.: | 111-18-2 |
|---|---|
| Name: | N,N,N',N'-Tetramethyl-1,6-hexanediamine |
| Article Data: | 33 |
| Molecular Structure: | |
|
|
|
| Formula: | C10H24N2 |
| Molecular Weight: | 172.314 |
| Synonyms: | Hexamethylenebis(dimethylamine);Kaolizer 1;Minico TMHD;N,N,N',N'-Tetramethyl-1,6-diaminohexane;N,N,N',N'-Tetramethyl-1,6-hexamethylenediamine;KL 1;N,N,N',N'-Tetramethylhexylenediamine;U-CAT 1000;1,6-Hexanediamine,N,N,N',N'-tetramethyl- (6CI,8CI,9CI);1,1,8,8-Tetramethyl-1,8-diazaoctane;1,6-Bis(dimethylamino)hexane;2,9-Dimethyl-2,9-diazadecane;U 1000 (amine);Toyocat MR;U 1000; |
| EINECS: | 203-842-9 |
| Density: | 0.827 g/cm3 |
| Melting Point: | -46 °C |
| Boiling Point: | 209.5 °C at 760 mmHg |
| Flash Point: | 73.9 °C |
| Solubility: | miscible with water |
| Appearance: | clear colorless to yellow liquid |
| Hazard Symbols: |
 T
|
| Risk Codes: | 22-24-34 |
| Safety: | 26-36/37/39-45 |
| Transport Information: | UN 3390 6.1/PG 1 |
| PSA: | 6.48000 |
| LogP: | 1.67000 |
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| Conditions | Yield |
|---|---|
| In tetrahydrofuran at 0 - 20℃; for 24h; | 100% |
| In chloroform at 20℃; for 24h; | 100% |
| With sodium carbonate In ethanol; water for 24h; Heating; | 98% |
| Conditions | Yield |
|---|---|
| With bis[dichloro(pentamethylcyclopentadienyl)ruthenium(III)]; bis[2-(diphenylphosphino)phenyl] ether; lithium tert-butoxide at 100℃; for 24h; | 95% |
| With [1,2,3,4,5-pentamethylcyclopentadiene*Ir(2,2'-bibenzimidazole)Cl]Cl; caesium carbonate at 120℃; for 12h; | 78% |
| With TiO2 supported nano-Pd(0.8) catalyst In water at 20℃; for 15h; Inert atmosphere; Irradiation; Green chemistry; | 96 %Chromat. |
| Conditions | Yield |
|---|---|
| With C22H19ClN5ORu(1+)*F6P(1-); caesium carbonate at 140℃; for 48h; | 57% |
- 124-09-4
1,6-Hexanediamine
- 50-00-0
formaldehyd
- 64-18-6
formic acid
- 111-18-2
N,N,N',N'-tetramethylhexamethylenediamine
| Conditions | Yield |
|---|---|
| 41% |
| Conditions | Yield |
|---|---|
| With formic acid; water |
- 104093-79-0
tetra-N-methyl-hex-3-ynediyldiamine
- 111-18-2
N,N,N',N'-tetramethylhexamethylenediamine
| Conditions | Yield |
|---|---|
| With ethanol; nickel |
- 104093-81-4
tetra-N-methyl-hex-2-ynediyldiamine
- 111-18-2
N,N,N',N'-tetramethylhexamethylenediamine
| Conditions | Yield |
|---|---|
| With ethanol; nickel |
| Conditions | Yield |
|---|---|
| With sulfuric acid Durch elektrolytische Reduktion an einer Bleikathode.; |
| Conditions | Yield |
|---|---|
| With ethanol |
- 50-00-0
formaldehyd
- 1938-58-5
N,N-dimethyl-1,6-hexanediamine
- 111-18-2
N,N,N',N'-tetramethylhexamethylenediamine
| Conditions | Yield |
|---|---|
| With formic acid |
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Chemistry
Molecular Formula: C10H24N2
Molar mass: 172.31 g/mol
EINECS: 203-842-9
Density: 0.827 g/cm3
Flash Point: 73.9 °C
Index of Refraction: 1.449
Boiling Point: 209.5 °C at 760 mmHg
Vapour Pressure: 0.202 mmHg at 25°C
Melting point: -46 °C
Water solubility: Miscible
Appearance: Clear colorless to yellow liquid
Product categories: Miscellaneous;Amine Monomers;Tertiary Amines
Structure of N,N,N',N'-Tetramethyl-1,6-hexanediamine (111-18-2):
XLogP3-AA: 1.7
H-Bond Donor: 0
H-Bond Acceptor: 2
IUPAC Name: N,N,N',N'-tetramethylhexane-1,6-diamine
Canonical SMILES: CN(C)CCCCCCN(C)C
InChI: InChI=1S/C10H24N2/c1-11(2)9-7-5-6-8-10-12(3)4/h5-10H2,1-4H3
InChIKey: TXXWBTOATXBWDR-UHFFFAOYSA-N
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 141mg/kg (141mg/kg) | International Journal of Neuropharmacology. Vol. 8, Pg. 131, 1969. | |
| rabbit | LD50 | skin | 492uL/kg (0.492mL/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | National Technical Information Service. Vol. OTS0536039, |
| rat | LCLo | inhalation | 410mg/m3/4H (410mg/m3) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA ENDOCRINE: CHANGES IN THYMUS WEIGHT BLOOD: CHANGES IN SPLEEN | National Technical Information Service. Vol. OTS0536940, |
| rat | LD50 | oral | 297uL/kg (0.297mL/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH MUSCULOSKELETAL: OTHER CHANGES | National Technical Information Service. Vol. OTS0536039 |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes: T.gif){kind=small}
Risk Statements:
22: Harmful if swallowed
24: Toxic in contact with skin
34: Causes burns
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Specification
N,N,N',N'-Tetramethyl-1,6-hexanediamine (111-18-2) also can be called Hexamethylenebis(dimethylamine) ; N,N,N',N`-Tetramethylhexanediamine ; 1,6-Bis(dimethylamino)hexane ; Toyocat MR ; Tetramethylhexamethylene diamine ; Koolizer 1 ; Minico TMHD .It is hazardous,so the first aid measures and others should be known.Such as: When on the skin: first,should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing. Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Do not induce vomiting.Wash mouth out with water,and get medical aid immediately.
In addition, N,N,N',N'-Tetramethyl-1,6-hexanediamine (111-18-2) can be stable under normal temperature and pressure conditions.It is not compatible with strong oxidizing agents, acids, carbon dioxide, anhydrous acids, acid chlorides, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: oxides of nitrogen, carbon dioxide, carbon monoxide.