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CAS No.: | 1125-70-8 |
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Name: | 2-phenylpropanamide |
Article Data: | 49 |
Molecular Structure: | |
Formula: | C9H11 N O |
Molecular Weight: | 149.192 |
Synonyms: | Hydratropamide(6CI,7CI,8CI); (RS)-2-Phenylpropionamide; (?à)-2-Phenylpropionamide; (?à)-Hydratropamide; (?à)-a-Methylbenzeneacetamide; 2-Phenylpropionamide; NSC 11140; NSC 59889; a-Phenylpropionamide |
Density: | 1.063g/cm3 |
Boiling Point: | 304.4°Cat760mmHg |
Flash Point: | 137.9°C |
PSA: | 43.09000 |
LogP: | 1.97570 |
Conditions | Yield |
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With dichloro( 1,5-cyclooctadiene)platinum(ll); 4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]phosphepine-4-oxide; water; silver nitrate In tert-Amyl alcohol at 80℃; for 1h; Catalytic behavior; Reagent/catalyst; Time; chemoselective reaction; | 99% |
With [RuH(tBu-PNP(-))(CO)]; water In tert-butyl alcohol at 20℃; for 24h; | 99% |
With sodium hydroxide; dihydrogen peroxide In methanol; water for 2h; pH=8.0; | 95% |
2-Phenylpropanal
2-phenylpropanamide
Conditions | Yield |
---|---|
With hydroxylamine; copper diacetate In water at 110℃; for 48h; | 99% |
Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran; acetonitrile / 0.17 h / 0 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C View Scheme |
C14H19N3O
2-phenylpropanamide
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.166667h; | 97% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.166667h; | 97% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.166667h; | 97% |
methanol
Benzeneacetamide
A
N-methyl-1-phenyl-1-methylacetamide
B
2-phenylpropanamide
Conditions | Yield |
---|---|
With C54H43ClN3P2Ru(1+)*F6P(1-); caesium carbonate In toluene at 140℃; for 12h; Inert atmosphere; Sealed tube; Green chemistry; | A 8% B 92% |
With C54H43ClN3P2Ru(1+)*F6P(1-); caesium carbonate In toluene at 140℃; for 48h; Inert atmosphere; Sealed tube; Green chemistry; | A 82% B 18% |
Conditions | Yield |
---|---|
90% |
Conditions | Yield |
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With bis(tri-t-butylphosphine)palladium(0); ammonium chloride In 1-methyl-pyrrolidin-2-one at 120℃; under 22801.5 Torr; for 15h; Catalytic behavior; Time; Reagent/catalyst; regioselective reaction; | 84% |
With bis(tri-t-butylphosphine)palladium(0); ammonium chloride In 1-methyl-pyrrolidin-2-one at 120℃; under 22801.5 Torr; for 24h; Autoclave; | 84% |
Conditions | Yield |
---|---|
With potassium phosphate; tetrakis(triphenylphosphine)nickel(0) In toluene at 60℃; for 16h; | 75% |
Conditions | Yield |
---|---|
With C54H43ClN3P2Ru(1+)*F6P(1-); caesium carbonate In toluene at 140℃; for 6h; Inert atmosphere; Sealed tube; Green chemistry; | 57% |
methyl 2-phenylpropanimidate
2-phenylpropanamide
Conditions | Yield |
---|---|
With aluminum oxide In methanol | 20% |
methanol
methyl hydratropimidate hydrochloride
A
2-phenylpropionic acid methyl ester
C
2-phenylpropanamide