CAS No.118289-55-7,5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one Suppliers

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Basic Information

Molecular Structure:
CAS No.:	118289-55-7
Name:	5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one
Article Data:	14

Formula:	C₁₀H₉Cl₂NO
Molecular Weight:	230.094
Synonyms:	5-(2-Chloroethyl)-6-chloro-1,3-dihydro-2H-indol-2-one;5-(2-Chloroethyl)-6-chlorooxindole;6-Chloro-5-(2-chloroethyl)-2-oxoindoline;6-Chloro-5-(2-chloroethyl)indolin-2-one;6-Chloro-5-(2-chloroethyl)oxindole;
EINECS:	421-320-0
Density:	1.376 g/cm³
Melting Point:	218-221oC
Boiling Point:	393.82 °C at 760 mmHg
Flash Point:	191.976 °C
Hazard Symbols:	N
Risk Codes:	50/53
Safety:	60-61
PSA:	29.10000
LogP:	2.75390

Synthetic route

: 6-chloro-5-(2-hydroxyethyl)-2-oxindole

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
With triphenylphosphine In tetrahydrofuran; tetrachloromethane for 3h; Reflux;	97%

: C17H16ClNO4S

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
With lithium chloride In N,N-dimethyl-formamide at 50℃; for 8h;	95%

: 118307-04-3
6-chloro-5-(2-chloroacetyl) indolin-2-one

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid
Stage #1: 6-chloro-5-(2-chloroacetyl) indolin-2-one With triethylsilane; trifluoroacetic acid at 0 - 35℃; for 7h; Stage #2: With water at 5 - 10℃; for 1h;
With triethylsilane In trifluoroacetic acid at -5 - 45℃; for 7.5h;

: 56341-37-8
6-chloro-2-oxindole

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / CS2 2: Et3SiH, CF3COOH View Scheme
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 1.2: 35 - 37 °C / Inert atmosphere 2.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 2.2: 0 - 35 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / dichloromethane / 0 °C / Inert atmosphere View Scheme

: 118307-04-3
6-chloro-5-(2-chloroacetyl) indolin-2-one

A: 884305-06-0
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

B: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid for 7h;
With aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 0℃; Inert atmosphere; chemoselective reaction;

: 884305-06-0
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
Stage #1: 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one With trifluoroacetic acid at 20℃; for 1h; Stage #2: With triethylsilane at 35 - 40℃; for 13.5 - 15.5h;
Stage #1: 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one With trifluoroacetic acid at 20℃; for 1h; Stage #2: With triethylsilane at 35 - 40℃; for 13.5 - 15.5h;

: 89-61-2
2,5-dichloronitrobenzene

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / dimethyl sulfoxide / 25 - 30 °C / Inert atmosphere 1.2: 16 h / 40 - 85 °C 2.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 3.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 3.2: 35 - 37 °C / Inert atmosphere 4.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 4.2: 0 - 35 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 4 steps
1.1: potassium carbonate / dimethyl sulfoxide / 25 - 30 °C / Inert atmosphere
1.2: 16 h / 40 - 85 °C
2.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C
3.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
3.2: 35 - 37 °C / Inert atmosphere
4.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere
4.2: 0 - 35 °C / Inert atmosphere
View Scheme

: 147124-32-1
dimethyl (4-chloro-2-nitrophenyl)malonate

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 2.2: 35 - 37 °C / Inert atmosphere 3.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 3.2: 0 - 35 °C / Inert atmosphere View Scheme

: 118307-04-3
6-chloro-5-(2-chloroacetyl) indolin-2-one

A: 884305-06-0
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

B: 6-chloro-5-ethylindolin-2-one

C: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
With triethylsilane; aluminum (III) chloride In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; Reflux;

...Expand

: 118307-04-3
6-chloro-5-(2-chloroacetyl) indolin-2-one

A: 6-chloro-5-ethylindolin-2-one

B: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions

Conditions	Yield
With aluminum (III) chloride; dimethylmonochlorosilane In dichloromethane at 0℃; Inert atmosphere; chemoselective reaction;

Raw Materials

89-61-2

118307-04-3

1481-68-1

56341-37-8

89-69-0

Downstream Products

122883-93-6

Total:125 Page 1 of 4 1 2 3 4 Next>>

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Chemistry

Molecular Structure of 2H-Indol-2-one,6-chloro-5-(2-chloroethyl)-1,3-dihydro- (CAS NO.118289-55-7):

Empirical Formula: C₁₀H₉Cl₂NO
Molecular Weight: 230.0906
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 29.1 Å²
Index of Refraction: 1.592
Molar Refractivity: 56.588 cm³
Molar Volume: 167.208 cm³
Surface Tension: 48.077 dyne/cm
Density: 1.376 g/cm³
Flash Point: 191.976 °C
Enthalpy of Vaporization: 64.376 kJ/mol
Boiling Point: 393.82 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Melting point: 218-221°C
Product Categories: Indole; Indoles; (intermediate of ziprasidone hcl); Intermediates of Ziprasidone

Safety Profile

Hazard Codes: Dangerous N
Risk Statements: 50/53
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 60-61
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.

Specification

2H-Indol-2-one,6-chloro-5-(2-chloroethyl)-1,3-dihydro- , with CAS number of 118289-55-7, can be called 2H-indole-2-one,5-chloroethyl-6-chloro-1,3-dihydro ; 5-chloroethyl-6-chloro-1,3-dihydro-1h-indol-2-one ; 5-chloroethyl-6-chloro-1,3-dihydro-2h-indole-2-one ; 6-chloro-5-(2-chloroethyl)-1,3-dihydro-2h-indol-2-one ; 5-(2-chloroethyl)-1,3-dihydro-2h-6-chloroindule-2-one ; 2h-indol-2-one-6-chloro-5-(2-chloroethyl)-1,3-dihydro ; 5-chloroethyl-6-chloro-1,3-dihydro-2h-indol-2-one ; 6-chloro-5-(2-chloroethyl)-1,3 .