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118647-53-3

Basic Information
CAS No.: 118647-53-3
Name: 3-(Bromomethyl)phenylacetic acid
Article Data: 16
Molecular Structure:
Molecular Structure of 118647-53-3 (3-(Bromomethyl)phenylacetic acid)
Formula: C9H9BrO2
Molecular Weight: 229.073
Synonyms: 3-BROMOMETHYLPHENYLACETIC ACID;3-bromomethyl carboxymethylbenzene;
Density: 1.565
Boiling Point: 341℃
Flash Point: 160℃
PSA: 37.30000
LogP: 2.20860
Synthetic route
621-36-3

m-methylphenylacetic acid

118647-53-3

(3-bromomethyl-phenyl)-acetic acid

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 16h; Reflux; Inert atmosphere;95%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 16h; Reflux;79.3%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 16h; Reflux;79.3%
67-56-1

methanol

118647-53-3

(3-bromomethyl-phenyl)-acetic acid

256382-37-3

3-methoxymethylphenylacetic acid

Conditions
ConditionsYield
With sodium methylate Inert atmosphere; Reflux;99%
118647-53-3

(3-bromomethyl-phenyl)-acetic acid

141337-05-5

2-(3-(bromomethyl)phenyl)ethanol

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 20℃; for 2h;94%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;94%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 13h;85%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 13h;71%
With borane-THF at 0℃;66%
127-09-3

sodium acetate

118647-53-3

(3-bromomethyl-phenyl)-acetic acid

1046492-41-4

(3-acetoxymethyl-phenyl)-acetic acid methyl ester

Conditions
ConditionsYield
In DMA at 120℃; for 4h; Irradiation;93%
118647-53-3

(3-bromomethyl-phenyl)-acetic acid

603-35-0

triphenylphosphine

1030893-55-0

[3-(carboxymethyl)benzyl](triphenyl)phosphonium bromide

Conditions
ConditionsYield
In acetonitrile for 16h; Heating / reflux;92.4%
67-56-1

methanol

118647-53-3

(3-bromomethyl-phenyl)-acetic acid

104508-22-7

methyl 2-(3-(bromomethyl)phenyl)acetate

Conditions
ConditionsYield
With thionyl chloride In toluene at 0℃; for 3h;72%
With hydrogenchloride at 0℃;
With thionyl chloride In toluene at 0℃;
118647-53-3

(3-bromomethyl-phenyl)-acetic acid

34956-29-1

2-(3-formylphenyl)acetic acid

Conditions
ConditionsYield
Stage #1: (3-bromomethyl-phenyl)-acetic acid With hexamethylenetetramine; water In ethanol for 4h; Reflux; Inert atmosphere;
Stage #2: With hydrogenchloride In ethanol; water for 0.5h; Reflux; Inert atmosphere;
72%
Stage #1: (3-bromomethyl-phenyl)-acetic acid With hexamethylenetetramine In ethanol; water for 10h; Reflux;
Stage #2: With hydrogenchloride In ethanol; water for 0.5h; Reflux;
66%
118647-53-3

(3-bromomethyl-phenyl)-acetic acid

2-(3-((nitrooxy)methyl)phenyl)acetic acid

Conditions
ConditionsYield
With silver nitrate In acetonitrile at 20℃; for 48h; Darkness;70%

sodium 6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidine-2-thiolate

118647-53-3

(3-bromomethyl-phenyl)-acetic acid

[3-(6-oxo-4-trifluoromethyl-1,6-dihydropyrimidin-2-ylsulfanylmethyl)phenyl]acetic acid

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃;45%

2-mercapto-6-oxo-4-(thiophen-2-yl)-1,6-dihydropyridine-3-carbonitrile

118647-53-3

(3-bromomethyl-phenyl)-acetic acid

[3-(3-cyano-6-oxo-4-thiophen-2-yl-1,6-dihydropyridin-2-ylsulfanylmethyl)phenyl]acetic acid

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide; acetone at 20℃;42%
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