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CAS No.: | 124858-35-1 |
---|---|
Name: | Nadifloxacin |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C19H21FN2O4 |
Molecular Weight: | 360.385 |
Synonyms: | 1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (±)-;Jinofloxacin;OPC 7251; |
EINECS: | 638-863-6 |
Density: | 1.467 g/cm3 |
Melting Point: | 245-247 °C |
Boiling Point: | 624.891 °C at 760 mmHg |
Flash Point: | 331.722 °C |
Appearance: | off-white crystalline solid |
PSA: | 82.77000 |
LogP: | 2.37210 |
4-HYDROXYPIPERIDINE
9-fluoro-8-bromo-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
nadifloxacin
Conditions | Yield |
---|---|
In N,N,N,N,N,N-hexamethylphosphoric triamide at 160℃; for 7h; | 25% |
6-fluoro-2-methyl-quinoline
nadifloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 87 percent / Br2, Ag2SO4, cc H2SO4, / 1 h 2: 68 percent / H2, / PtO2, / acetic acid / Ambient temperature 3: 2.) PPA, 3.) cc HCl, / 1.) 150 deg C, 1 h, 2.) 150 deg C, 30 min, 3.) AcOH, H2O, reflux, 2 h, 4: 25 percent / hexamethylphosphoric acid triamide / 7 h / 160 °C View Scheme |
5-bromo-6-fluoro-2-methylquinoline
nadifloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 68 percent / H2, / PtO2, / acetic acid / Ambient temperature 2: 2.) PPA, 3.) cc HCl, / 1.) 150 deg C, 1 h, 2.) 150 deg C, 30 min, 3.) AcOH, H2O, reflux, 2 h, 3: 25 percent / hexamethylphosphoric acid triamide / 7 h / 160 °C View Scheme |
5-bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
nadifloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2.) PPA, 3.) cc HCl, / 1.) 150 deg C, 1 h, 2.) 150 deg C, 30 min, 3.) AcOH, H2O, reflux, 2 h, 2: 25 percent / hexamethylphosphoric acid triamide / 7 h / 160 °C View Scheme |
nadifloxacin
methyl iodide
methyl-9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H-benzoquinolizine-2-carboxylate
Conditions | Yield |
---|---|
With potassium hydroxide In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol at 60℃; for 1.5h; | 91% |
4-((6,7-dimethoxyquinazolin-4-yl)oxy)-3-fluoroaniline
nadifloxacin
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; | 70% |
nadifloxacin
acetic acid
8-(4-acetoxy-1-piperidyl)-9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzoquinolizine-2-carboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid In dichloromethane for 5h; Heating; | 57% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 22℃; for 13h; Inert atmosphere; | 24% |
nadifloxacin
9-fluoro-6,7-dihydro-5-methyl-8-(4-sulfoxy-1-piperidyl)-1-oxo-1H,5H-benzoquinolizine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 91 percent / 85percent potassium hydroxide / hexamethylphosphoric acid triamide; ethanol / 1.5 h / 60 °C 2: 1) chlorosulfonic acid / 1) 50-55 deg C, 30 min, 2a) 50-55 deg C, 6 h, 2b) r.t., overnight 3: 38 percent / 0.1N KOH / methanol View Scheme |
nadifloxacin
pyridinium 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-2-methoxycarbonyl-5-methyl-1-oxo-1H,5H-benzoquinolizine sulfate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / 85percent potassium hydroxide / hexamethylphosphoric acid triamide; ethanol / 1.5 h / 60 °C 2: 1) chlorosulfonic acid / 1) 50-55 deg C, 30 min, 2a) 50-55 deg C, 6 h, 2b) r.t., overnight View Scheme |
The Nadifloxacin, with the CAS registry number 124858-35-1, is also known as 1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (±)-. It belongs to the product categories of Intermediates & Fine Chemicals; Pharmaceuticals. This chemical's molecular formula is C19H21FN2O4 and molecular weight is 360.38. What's more, its systematic name is 9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. This chemical is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. It is also used to treat bacterial skin infections.
Physical properties of Nadifloxacin are: (1)ACD/LogP: 2.491; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.25; (4)ACD/LogD (pH 7.4): 0.71; (5)ACD/BCF (pH 5.5): 26.17; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 306.78; (8)ACD/KOC (pH 7.4): 8.90; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 81.08 Å2; (13)Index of Refraction: 1.669; (14)Molar Refractivity: 91.62 cm3; (15)Molar Volume: 245.686 cm3; (16)Polarizability: 36.321×10-24cm3; (17)Surface Tension: 71.7 dyne/cm; (18)Density: 1.467 g/cm3; (19)Flash Point: 331.722 °C; (20)Enthalpy of Vaporization: 97.264 kJ/mol; (21)Boiling Point: 624.891 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)\C2=C\N4c1c(c(c(F)cc1C2=O)N3CCC(O)CC3)CCC4C
(2)Std. InChI: InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
(3)Std. InChIKey: JYJTVFIEFKZWCJ-UHFFFAOYSA-N