Reference

Piperidine derivatives

Piperidine derivatives. Hydro, William R. (United States Dept. of the Army, USA). U.S. 63645-21-6 is the cas registry number. This chemical is also mentioned in this article. US 4032531 28 Jun 1977, 4 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07D211-06. NCL: 260293640. APPLICATION: US 69-882757 3 Dec 1969. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) 4-Piperidinol diesters I [R and n = 2-thienyl, 4 (II); Ph, 2] were prepd. by treatment of the appropriate 4-piperidinol deriv. with adipyl or succinyl chloride. I decreased muscle tone in mice. Thus, adipyl chloride in HCCl3 was added dropwise to a soln. of III, Na2CO3, and H2O in HCCl3 and the mixt. stirred for 5 h to give II (isolated as the dihydrochloride). .

4-Piperidinol derivatives

4-Piperidinol derivatives. Ikawa, Kenji; Tokuyama, Kanji; Kiyokawa, Masumi; Maezono, Norihide; Tokuno, Noboru; Maeda, Takashi; Uno, Ikuo (Shionogi and Co., Ltd., Japan). Japan. Kokai JP 51118769 18 Oct 1976 Showa, 6 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D211-52. APPLICATION: JP 75-42564 8 Apr 1975. 3308-94-9 and 52-86-8 are also in the experiment. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 17 I (R = Cl, Me) were prepd. by relfuxing HN(CH2CH2CO2Me)2 with the ethylene ketal of 4-FC6H4CO(CH2)3Cl and NaHCO3 in PhMe to give 83.5% the ethylene ketal (II) of 4-FC6H4CO(CH2)3N(CH2CH2CO2Me)2, cyclization of II in C6H6 with Na-MeOH to give 93.3% III, refluxing III in 1:6 H2O-MeOH to give 58% ethylene ketal of (IV) of V, deketalization of IV by heating in 50% AcOH to give 82.7% V, and Grignard reaction of V with 4-RC6H4MgBr. .