Reference

Drug-induced changes in serum alkaline phosphatase and alanine aminotransferase activities not related to hepatic injuries

Drug-induced changes in serum alkaline phosphatase and alanine aminotransferase activities not related to hepatic injuries. Balazs, T.; Farber, T. M.; Feuer, G. (Food Drug Adm., Washington, D. C., USA). Arch. Toxikol., (Suppl. 1, Toxicol. Aspects Food Saf.), 159-63 (English) 1978. CODEN: ATXKA8. ISSN: 0003-9446. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In dogs treated orally with phenobarbital [50-06-6], diphenylhydantoin [630-93-3], primidone [125-33-7], or polybrominated biphenyls, only phenobarbital increased serum alk. phosphatase [9001-78-9]. No histol. changes were obsd. in the liver of any of the treated dogs. Cefazolin [25953-19-9] was given s.c. to rats at 2 g/kg/day on days 1-18 and at 0.5 g/kg/day on days 19-32. Isoniazid [54-85-3] was given orally at 20 mg/kg/day for 33 days to a similar group. Half of each group received pyridoxal-HCl [65-22-5], s.c., at 0.2 mg/kg/day on days 1-18 and at 2 mg/kg/day on days 19-46. Serum alanine aminotransferase [9000-86-6] decreased in each group, but returned to normal on day 32 in rats dosed with the isoniazid-pyridoxal combination. Isoniazid is known to interfere with alanine aminotransferase activity by decreasing the availability of the coenzyme. The mechanism of cefazolin has not been elucidated.

Simultaneous gas chromatographic determination of diphenylhydantoin, carbamazepine (tegretol), phenobarbital and primidone in presence of kemadrin (procyclidine) and prolixin (fluphenazine) in plasma of psychiatric patients

Simultaneous gas chromatographic determination of diphenylhydantoin, carbamazepine (tegretol), phenobarbital and primidone in presence of kemadrin (procyclidine) and prolixin (fluphenazine) in plasma of psychiatric patients. Varma, Rajendra (Biochem. Dep., Warren State Hosp., Warren, Pa., USA). J. Chromatogr., 155(1), 182-6 (English) 1978. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A gas chromatog. method for the simultaneous detn. of diphenylhydantoin (I) [57-41-0], carbamazepine (II) [298-46-4], phenobarbital (III) [50-06-6], and primidone (IV) [125-33-7] in the presence of Kemadrin [77-37-2] and Prolixin [146-56-5] is described. The blood sample is extd. with CH2Cl2 and sepd. on a glass column packed with 3% OV-17 on Chromosorb W HP using N as the carrier gas. A recovery of 98-100% was obsd. The limit of detection is approx. 0.5 mg/mL. The procedure is highly reproducible with variations from 0.5-1.3 mg/mL. Kemadrin and Prolixin did not interfere with the detn. of I, II, III, and IV.