Reference

CB1 receptor signaling modulators and polypeptides with CB1 receptor affinity for treatment of lymphoproliferative disorders, screening methods, and diagnostic methods

CB1 receptor signaling modulators and polypeptides with CB1 receptor affinity for treatment of lymphoproliferative disorders, screening methods, and diagnostic methods. Sander, Birgitta; Christensson, Birger; Smith, Edvard; Kimby, Eva ( Affibody AB, Swed.). PCT Int. Appl. WO 2005023232 A2 17 Mar 2005, 49 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K031-00. ICS: A61K031-454; A61K031-5383; A61K031-164; A61P035-00; G01N033-94; A61K039-395. APPLICATION: WO 2004-SE1277 6 Sep 2004. PRIORITY: US 2003-PV499901 4 Sep 2003. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 9, 14 The invention provides the use of a compd. capable of modulating CB1 receptor signaling, or of a polypeptide with a biospecific affinity for the CB1 receptor, for the prepn. of a medicament for treatment of a lymphoproliferative disorder involving cells with abnormal CB1 receptor function. Furthermore, the invention provides methods for identification of a compd. capable of modulating CBI receptor signaling, a method for the diagnosis of a lymphoproliferative disorder involving cells with abnormal CBI receptor function in a subject, a method for treatment of a lymphoproliferative disorder involving cells with abnormal CB1 receptor function, and a method for elimination of malignant lymphocytes from a cell population.Some commonly used reagents like 131543-23-2 is used in this experiment. .