CAS No.132-22-9,Chloropheniramine-d4 Suppliers

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Basic Information

Molecular Structure:
CAS No.:	132-22-9
Name:	Chloropheniramine-d4
Article Data:	20

Formula:	C16H19 Cl N2
Molecular Weight:	274.793
Synonyms:	Pyridine,2-[p-chloro-a-[2-(dimethylamino)ethyl]benzyl]-(8CI); (?à)-Chloropheniramine; (?à)-Chlorpheniramine;1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 2-[p-Chloro-a-[2-(dimethylamino)ethyl]benzyl]pyridine;3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine; 4-Chloropheniramine;Allergican; Chloropheniramine; Chlorophenylpyridamine; Chloroprophenpyridamine;Chlorphenamine; Chlorpheniramine; Chlorprophenpyridamine; Haynon;RS-Chlorpheniramine;dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propane; g-(4-Chlorophenyl)-g-(2-pyridyl)propyldimethylamine
Density:	1.107g/cm³
Melting Point:	25°C
Boiling Point:	379°Cat760mmHg
Flash Point:	183°C
Solubility:	5.496g/L(37.5 oC)
Safety:	Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
PSA:	16.13000
LogP:	3.81860

Synthetic route

: 55486-47-0
3-(p-chlorophenyl)-3-(2-pyridyl)propanal

: 124-40-3
dimethyl amine

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In toluene at 120℃; under 38000 Torr; for 12h; catalytic reductive amination;	100%

: 65676-21-3
chloropheniramine nitrile

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With potassium hydroxide at 160℃; for 4h;	95%

: 73486-85-8
3-(4-chlorophenyl)-3-pyridin-2-yl-propan-1-ol

: 124-40-3
dimethyl amine

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; bis[2-(diphenylphosphino)phenyl] ether In toluene at 20℃; Inert atmosphere; Reflux;	81%

: 73775-50-5
2-(4-chloro-phenyl)-4-dimethylamino-butyronitrile

: 74-86-2
acetylene

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
(η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I) In toluene at 140℃; under 10640 Torr; for 36h;	75%

: 160911-84-2
1-(4-chlorophenyl-1-(2-pyridyl))ehylene

: C12H12N2O4

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 0.8C12H6N2O4(2-)HO(1-)Al(3+)0.4CF3O3S(1-)0.1Ir(3+)0.2C11H8N(1-)0.1Cl(1-) In acetonitrile at 20℃; for 6h; Inert atmosphere; Irradiation;	36%

: 109-04-6
2-bromo-pyridine

: 140-53-4
p-chlorobenzyl cyanide

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With sodium amide; benzene anschl. mit <2-Chlor-aethyl>-dimethyl-amin und anschl. Erhitzen mit wss. H2SO4;
With sodium amide; benzene anschl. mit <2-Chlor-aethyl>-dimethyl-amin und anschl. Erhitzen mit NaOH in Butan-1-ol;

: 4350-41-8
2-(4-chlorobenzyl)pyridine

: 107-99-3
2-(dimethylamino)ethyl chloride

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With potassium amide
With sodium amide
Stage #1: 2-(4-chlorobenzyl)pyridine With sodium amide In tetrahydrofuran at 20 - 25℃; for 1h; Stage #2: 2-(dimethylamino)ethyl chloride In tetrahydrofuran; toluene at 30 - 45℃; for 2h;

: 2138-38-7
1-(4-chlorophenyl)-3-dimethylamino-1-propanone

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With 2-pyridyllithium; diethyl ether

: 88848-63-9
1t-(4-chloro-phenyl)-3-dimethylamino-1c-[2]pyridyl-propene

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;

(+-)-2-<4-chloro-phenyl>-4-dimethylamino-2-<2>pyridyl-butyric acid dimethylamide: (+-)-2-<4-chloro-phenyl>-4-dimethylamino-2-<2>pyridyl-butyric acid dimethylamide

: 132-22-9
Chlorpheniramine

Conditions

Conditions	Yield
With sulfuric acid; water

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Chemistry

Chemistry informtion about Chlorpheniramine (CAS NO.132-22-9) is:
IUPAC Name: 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Synonyms: Chlorpheniramine ; Dl-Chlorpheniramine
MF: C₁₆H₁₉ClN₂
MW: 274.79
Density: 1.107 g/cm³
Flash Point: 183 °C
Boiling Point: 379 °C at 760 mmHg
Enthalpy of Vaporization: 62.7 kJ/mol
Vapour Pressure: 6.04E-06 mmHg at 25°C
Following is the molecular structure of Chlorpheniramine (CAS NO.132-22-9) is:

Uses

Chlorpheniramine (CAS NO.132-22-9) is often combined with phenylpropanolamine to form an allergy medication with both antihistamine and decongestant properties.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	125mg/kg (125mg/kg)	Yakugaku Zasshi. Journal of Pharmacy. Vol. 92, Pg. 1339, 1972.
mouse	LD50	intravenous	20mg/kg (20mg/kg)	Medizinische Welt. Vol. 17, Pg. 2791, 1966.
mouse	LD50	oral	121mg/kg (121mg/kg)	Medizinische Welt. Vol. 17, Pg. 2791, 1966.
mouse	LD50	subcutaneous	160mg/kg (160mg/kg)	Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
rabbit	LD50	intravenous	22mg/kg (22mg/kg)	Medizinische Welt. Vol. 17, Pg. 2791, 1966.
rat	LD50	oral	118mg/kg (118mg/kg)	Medizinische Welt. Vol. 17, Pg. 2791, 1966.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.