Detail of "136310-93-5"

CAS Number:
136310-93-5
Name:
3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide (1:1), (1a,2b,4b,5a,7b)-
Superlist Name:
Tiotropium bromide
Molecular Structure:
Formula:
C₁₉H₂₂BrNO₄S₂
Molecular Weight:
472.42
Synonyms:
3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, (1a,2b,4b,5a,7b)- (9CI);(1a,2b,4b,5a,7b)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-di-methyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonanebromide;BA 679BR;Spiriva;tiopropium;
Appearance:
White solid

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Reference

Oxygen-containing heterocycles as PDE IV inhibitors, pharmaceutical compositions containing them and anticholinergic agents, uses of the compositions for treatment of COPD or asthma, and pharmaceutical kits containing both components: Oxygen-containing heterocycles as PDE IV inhibitors, pharmaceutical compositions containing them and anticholinergic agents, uses of the compositions for treatment of COPD or asthma, and pharmaceutical kits containing both components. Abe, Yuzuru; Miki, Ichiro (Kyowa Hakko Kogyo Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 2005015394 A2 20 Jan 2005, 17 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: A61K031-357. ICS: A61K031-12; A61K031-137; A61K031-216; A61K031-46; A61K045-00; A61P011-00; A61P011-06; A61P043-00. APPLICATION: JP 2003-182385 26 Jun 2003. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The compns. contain (a) O-contg. benzoheterocycles I [m = 0-4; R1-R4 = H, lower alkyl, cycloalkyl, lower alkenyl, cycloalkenyl, aryl, aralkyl; 2 of R1-R4 on the same C are bonded together to form a spiro ring; adjacent 2 of R1-R4 may be bonded together to form a condensed ring or form a double bond; R5 = lower (halo)alkoxy; R6 = H, halo; Y = Q; R7 = cyano, ethynyl, carbamoyl; R8 = H, 4-carboxyphenyl; R7 andR8 may be bonded together to form a double bond] or their pharmacol. acceptable salts and (b) anticholinergic agents.There are some commonly used reagents with their cas registry numbers 136310-93-5 and 208043-38-3 in this article. COPD or asthma is treated by administering (a) and (b) simultaneously or sep. with some time interval. Thus, tablets were formulated contg. cis-4-cyano-4-(8-methoxy-1,4-benzodioxan-5-yl)cyclohexanecarboxylic acid and oxybutynin hydrochloride. .

Tiotropium bromide: a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease: Tiotropium bromide: a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease. Joos, G. F.; Brusselle, G. 136310-93-5 are also occured in this study.; Derom, E.; Pauwels, R. (Department of Respiratory Diseases, Ghent University Hospital, Ghent B9000, Belg.). International Journal of Clinical Practice, 57(10), 906-909 (English) 2003 Blackwell Publishing Ltd. CODEN: IJCPF9. ISSN: 1368-5031. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review. Prevention and relief of symptoms by regular use of bronchodilators is central to the management of patients with chronic obstructive pulmonary disease (COPD). The bronchodilators in use are b2-agonists, anticholinergics and theophylline. Since the 1970s the anticholinergic ipratropium bromide has been widely used for the treatment of patients with regular symptoms, but because it has a relatively short duration of action, it needs to be administered four times a day. Tiotropium bromide is a long-acting anticholinergic suitable for once daily administration. It has been developed as a dry powder inhaler for the treatment of patients with COPD. Large clin. trials with administration of the drug for one year have now been published. Compared with placebo and ipratopium bromide, significant and long-lasting bronchodilatation was obsd., which was maintained over the year. The bronchodilator effect of tiotropium bromide was accompanied by improvements in other health outcomes. A significant decrease in dyspnea, improvement in health-related quality of life, and a redn. in the no. of COPD exacerbations and hospitalizations were noted. In this review we summarize the clin. development of this compd. .

Detail of "136310-93-5"

3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide (1:1), (1a,2b,4b,5a,7b)-

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CAS No.136310-93-5 Tiotropium bromide

CAS No.136310-93-5 Tiotropium bromide

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Reference