CAS No.138-56-7,Trimethobenzamide Suppliers

Products Categories

Pharmaceutical (45)
Organic Chemicals (13)
Others (10)
Reagent (2)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	138-56-7
Name:	Trimethobenzamide
Article Data:	9

Formula:	C₂₁H₂₈N₂O₅
Molecular Weight:	388.464
Synonyms:	Benzamide,N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxy- (6CI,7CI,8CI);4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine;Emedur;N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide;Trimethobenzamide;
EINECS:	205-332-1
Density:	1.131 g/cm³
Boiling Point:	506.9 °C at 760 mmHg
Flash Point:	260.4 °C
PSA:	69.26000
LogP:	2.97370

Synthetic route

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 201230-82-2
carbon monoxide

: 20059-73-8
4-<2-(dimethylamino)ethoxy>benzylamine

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
With triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 80℃; for 18h; Glovebox; Sealed tube; Inert atmosphere;	99%

...Expand

: 20059-73-8
4-<2-(dimethylamino)ethoxy>benzylamine

: tert-butyl phenyl(3,4,5-trimethoxybenzoyl)carbamate

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 15h; Schlenk technique; Inert atmosphere;	94%

: 3840-31-1
(3,4,5-trimethoxyphenyl)methanol

: 20059-73-8
4-<2-(dimethylamino)ethoxy>benzylamine

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
With potassium tert-butylate; [Ru(PtBuNNHBn)H(CO)Cl] In tert-butyl methyl ether at 70℃; under 760.051 Torr; for 60h; Inert atmosphere;	94%

: 3086-62-2
3,4,5-trimethoxybenzamide

: 131028-54-1
(4-(2-(dimethylamino)ethoxy)phenyl)methanol

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
With 1,10-Phenanthroline; nickel dibromide; sodium t-butanolate In toluene at 130℃; for 48h; Schlenk technique; Inert atmosphere;	80%

: 20059-73-8
4-<2-(dimethylamino)ethoxy>benzylamine

: 118-41-2
Eudesmic acid

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
With 6,6'-diselanediylbis(N-(2-(dimethylamino)ethyl)-3-nitrobenzamide); oxygen; triethyl phosphite In acetonitrile at 30℃; for 18h; Molecular sieve;	73%

: 20059-73-8
4-<2-(dimethylamino)ethoxy>benzylamine

: 118-41-2
Eudesmic acid

A: 138-56-7
Trimethobenzamide

B: 1445977-41-2
C30H36N2O9

C: 1445977-42-3
trimethobenzamide

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide Reagent/catalyst;	A n/a B 0.5% C 4%

...Expand

: 20059-73-8
4-<2-(dimethylamino)ethoxy>benzylamine

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 138-56-7
Trimethobenzamide

: 118-41-2
Eudesmic acid

2-oxy-4.6.ω-trimethoxy-acetophenone: 2-oxy-4.6.ω-trimethoxy-acetophenone

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 / 0.5 h / Heating 2: Et3N / CHCl3 / 2 h / Ambient temperature View Scheme

: 15182-92-0, 87330-48-1
4-(2-dimethylaminoethoxy)benzaldehyde

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Raney nickel; ethanol; NH3 / 80 °C / 51485.6 Torr / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: ammonia / methanol / 8 h / 50 - 55 °C / 6000.6 - 7500.75 Torr / Large scale 2: potassium carbonate / ethyl acetate / 2.5 h / 10 °C / Inert atmosphere; Large scale View Scheme

: 123-08-0
4-hydroxy-benzaldehyde

: 138-56-7
Trimethobenzamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium methylate; chlorobenzene 2: Raney nickel; ethanol; NH3 / 80 °C / 51485.6 Torr / Hydrogenation View Scheme
Multi-step reaction with 3 steps 1: sodium carbonate / butanone / 18 h / 25 - 80 °C / Large scale 2: ammonia / methanol / 8 h / 50 - 55 °C / 6000.6 - 7500.75 Torr / Large scale 3: potassium carbonate / ethyl acetate / 2.5 h / 10 °C / Inert atmosphere; Large scale View Scheme

Country:
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:62 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 138-56-7

Specification

The Trimethobenzamide, with the CAS registry number 138-56-7, is also known as 4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine. Its EINECS registry number is 205-332-1. This chemical's molecular formula is C₂₁H₂₈N₂O₅ and molecular weight is 388.46. Its IUPAC name is called N-[[4-(2-dimethylaminoethyloxy)phenyl]methyl]-3,4,5-trimethoxybenzamide. This chemical's classification codes are Antiemetics; Autonomic Agents; Central Nervous System Agents; Gastrointestinal Agents; Peripheral Nervous System Agents. This chemical is an antiemetic used to prevent nausea and vomiting. Trimethobenzamide is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems, so it has a lower likelihood of causing undesired side effects.

Physical properties of Trimethobenzamide: (1)ACD/LogP: 1.85; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.96; (4)ACD/LogD (pH 7.4): 0.6; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 13.58; (9)#H bond acceptors: 7; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 10; (12)Index of Refraction: 1.546; (13)Molar Refractivity: 108.69 cm³; (14)Molar Volume: 343.2 cm³; (15)Surface Tension: 40.1 dyne/cm; (16)Density: 1.131 g/cm³; (17)Flash Point: 260.4 °C; (18)Enthalpy of Vaporization: 77.69 kJ/mol; (19)Boiling Point: 506.9 °C at 760 mmHg; (20)Vapour Pressure: 2.13E-10 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C(=C2)OC)OC)OC
(2)InChI: InChI=1S/C21H28N2O5/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24)
(3)InChIKey: FEZBIKUBAYAZIU-UHFFFAOYSA-N