Reference

Disposition of sulfonamides in food-producing animals

Disposition of sulfonamides in food-producing animals. V: Disposition of sulfathiazole in tissue, urine, and plasma of sheep following intravenous administration. Bevill, Richard F.; Koritz, Gary D.; Dittert, Lewis W.; Bourne, David W. A. (Coll. Vet. Med., Univ. Illinois, Urbana, Ill., USA). J. Pharm. Sci., 66(9), 1297-300 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 17 (Foods) Section cross-reference(s): 1 The plasma, urine, and tissue sulfathiazole (I) concns. were detd. at various times following i.v. administration of I Na [144-74-1] to lambs. The plasma and urine data were consistent with a one-compartment pharmacokinetic model, with an elimination half-life of 1.1 h and a vol. of distribution of 0.39 L/kg. I was eliminated be excretion of unchanged drug in urine (67%) and by formation of two metabolites. The data obtained from eight tissue sites were consistent with the one-compartment pharmacokinetic model presented and confirmed that tissue residues of I can be calcd. from serum and urine drug concns.

Heat of solution of the sodium salts of some sulfanilamides in water

Heat of solution of the sodium salts of some sulfanilamides in water. Raspopov, E. I.; Vol'naya, L. P. (Pyatigorsk. Farm. Inst., Pyatigorsk, USSR). Khim.-Farm. Zh., 11(10), 121-2 (Russian) 1977. CODEN: KHFZAN. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 The heat of soln. (.DELTA.H) for ethazole Na salt [1904-95-6], norsulfazole Na salt [144-74-1], and sulfacyl Na salt [127-56-0] in water at 298.degree. was calcd. to be 1.67 .+-. 0.094, 2.38 .+-. 0.29, and 1.38 .+-. 0.25 kcal/mol, resp.