Detail of "14838-15-4"

Reference

Evaluation of flow cytometric cell cycle data on cultured murine splenocytes exposed to selected chemical agents

Evaluation of flow cytometric cell cycle data on cultured murine splenocytes exposed to selected chemical agents. Anson, J.; Hinson, W. G. (Natl. Cent. Toxicol. Res., Jefferson, AR, USA). Report, NCTR/E-6174, FDA/NCTR-84/75; Order No. PB84-193135, 22 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1984, 84(16), 67 (English) 1983. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) Cycloheximide [66-81-9] when added to the proliferating splenocyte system at 0.005 mg/mL caused restriction of cells in the late G1 phase of the cell cycle and delayed the passage of cells into the S and G2 + M phases. Cycloheximide was chosen as a pos. control. Mitomycin C [50-07-7], a cell blocking agent, produced inconsistent results using the splenocyte system and was ruled out as a pos. control. Butylated hydroxytoluene (BHT) [128-37-0], at a threshold dose of 20 mg/mL in the splenocyte system, enhanced the G1 phase and shortened the cell cycle in agreement with published reports. Phenylpropanolamine [14838-15-4], at a threshold dose of 100 mg/mL in the splenocyte system, caused a complete depression of the cell cycle with little or no indication of cellular toxicity. Anal. of this data detd. a minimal ED for each compd. thereby meeting the exptl. goal of quantitation of cell cycle perturbation.

Bare silica as a reverse-phase stationary phase: liquid chromatographic separation of antihistamines with buffered aqueous organic mobile phases

Bare silica as a reverse-phase stationary phase: liquid chromatographic separation of antihistamines with buffered aqueous organic mobile phases. Richardson, Harold; Bidlingmeyer, Brian A. (Waters Assoc., Milford, MA 01757, USA). J. Pharm. Sci., 73(10), 1480-2 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 80 Unbonded silica gel is an effective support for reversed-phase liq. chromatog. sepns. of lipophilic amines. Simple buffered aq.-org. mobile phases provide rapid isocratic sepns. of antihistamines. Phenylpropanolamine [14838-15-4], chlorpheniramine maleate [113-92-8], and dextromethorphan [125-71-3] are sepd. in 8 min on bare silica with a mobile phase of mixt. of MeOH and H2O contg. 0.01M (NH4)2HPO4. Quantitation is reproducible. A wide variety of addnl. compds. may be sepd. using the same mobile phase.