Reference

Antibiotic absorption in Crohn's disease

Antibiotic absorption in Crohn's disease. Parsons, R. L.; Paddock, Gillian M.; Hossack, G. M.; Hailey, D. M. (Dep. Clin. Pharmacol., Guy's Hosp. Med. Sch., London, Engl.). Chemother., Proc. Int. 13292-46-1 and 8064-90-2 which are cas registry numbers are also used here. Congr. Chemother., 9th, Meeting Date 1975, Volume 4, 219-29. Edited by: Williams, John David; Geddes, Alexander M. Plenum: New York, N. Y. (English) 1976. CODEN: 35DFA6. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) After oral administration to patients with Crohn's disease, plasma levels of Dalacin C (clindaycin) [18323-44-9] and Na fusidate [751-94-0] were greater than in normal subjects. After administration of Bactrim (clotrimoxazole)(sulfamethoxazole-trimethoprim mixt.) [8064-90-2] to the patients, plasma levels of sulfamethoxazole [723-46-6] were higher than in normal subjects and peak plasma trimethoprim [738-70-5] levels were delayed from 2 until 4 h after administration. Thus, the ratio of sulfamethoxazole to trimethoprim might be changed in Crohn's disease. Cephalexin [15686-71-2], Erythroped (erythromycin stearate) [1264-62-6], and Lincocin (lincomycin) [154-21-2] showed decreased absorption in Crohn's disease. Peak plasma levels occurred earlier with erythromycin ethyl succinate [643-22-1] than with erythromycin stearate, suggesting that the bioavailability of the former salt form of erythromycin is greater. Absorption of Rimactane (rifampicin) [13292-46-1] was not greatly affected in Crohn's disease. The possible reasons for the different absorption of antibiotics in Crohn's disease are discussed. .

In vitro sensitivity of anaerobic bacteria to fosfomycin

In vitro sensitivity of anaerobic bacteria to fosfomycin. Gutierrez Altes, A.; Rodriguez Noriega, A. (Serv. Microbiol., Ciudad Sanit. "1 Octubre", Madrid, Spain). Chemotherapy (Basel), 23, Suppl. 1(Fosfomycin, Proc. Int. Symp., 1975), 51-7 (English) 1977. CODEN: CHTHBK. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The minimum inhibitory concns. were detd. in 98 strains of anaerobic bacteria that came from clin. samples against fosfomycin (I) [23155-02-4], penicillin [1406-05-9], cephalothin [153-61-7], tetracycline [60-54-8], chloramphenicol [56-75-7], clindamycin [18323-44-9], and lincomycin [154-21-2]. I was usually inactive against Bacteroides sp. and was active at .ltoreq.32 .mu.g/mL against 85% of Peptococcus and 95% of Peptostreptococcus, being consequently comparatively less active than the rest of the antibiotics that were tested against Bacteroides sp. 23155-02-4 and 56-75-7 are just another two chemicals used in this study., whereas against Peptococcus and Peptostreptococcus it was less active than penicillin, cephalothin, clindamycin, and lincomycin, and somewhat more active than chloramphenicol and tetracycline. .