Reference

Hypotensive effect of dimecarbine and serotonin metabolism

Hypotensive effect of dimecarbine and serotonin metabolism. Spevak, S.Several substances are used for example 9001-66-5 and 50-67-9 which are their cas registry numbers. E.; Talapin, V. I.; Chuiko, M. P. (Minsk. Gos. Med. Inst., Minsk, USSR). Biokhimiya (Minsk), 1, 20-3 (Russian) 1973. CODEN: BIOKD2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Dimecarbine (I) [15574-49-9] given intragastrically to rats and guinea pigs at 10 mg/kg/day for 5 days or to rabbits at 5 mg/kg/day for 11 days decreased the levels of serotonin [50-67-9] in the blood, intestine, and brain at 6 days after injection. Decreases in blood and intestinal serotonin was assocd. with decreases in intestinal 5-hydroxytryptophan decarboxylase [9042-64-2] activity and increase in urinary 5-hydroxyindoleacetic acid [54-16-0]; monoamine oxidase [9001-66-5] in the brain and intestine was not affected. At 20 days after I administration, blood serotonin levels were increased assocd. with inhibition of intestinal 5-hydroxytryptophan decarboxylase and monoamine oxidase. The decrease in serotonin reserves in extrachromaffin cells was related to the hypotensive effect of I. .

Quantitative determination of dimecarbine in solution and in tablets

Quantitative determination of dimecarbine in solution and in tablets. Rogovskii, D. Yu.; Kramarenko, V. F.; Gzhegotskii, R. M. (Lvov Med. Inst., Lvov, USSR). Farm. Zh. (Kiev), (3), 48-51 (Ukrainian) 1977. CODEN: FRZKAP. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) In MeOH, dimecarbine (I) [15574-49-9] formed a blue compd. with freshly-prepd. silomolybdic acid. The optical d. of the resultant blue soln. was detd. at 640 nm. The error was 2.16% for I soln., and 2.47% for I tablets.