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CAS No.: | 180181-93-5 |
---|---|
Name: | 3-N-FMOC-3-PHENYLPROPIONIC ACID |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C24H21NO4 |
Molecular Weight: | 387.435 |
Synonyms: | 3-(9 h-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionic acid;Fmoc-3-amino-3-phenylpropionic acid; |
Density: | 1.275 g/cm3 |
Boiling Point: | 617 °C at 760 mmHg |
Flash Point: | 326.9 °C |
Hazard Symbols: | N |
Risk Codes: | 50 |
Safety: | 61 |
PSA: | 75.63000 |
LogP: | 5.13200 |
(fluorenylmethoxy)carbonyl chloride
3-Amino-3-phenylpropionic acid
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃; for 25h; | 100% |
With sodium hydroxide In 1,4-dioxane at 20℃; for 4h; | 77% |
With N-ethyl-N,N-diisopropylamine |
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
With acetic acid; zinc In tetrahydrofuran; water at 40℃; for 4h; Inert atmosphere; chemoselective reaction; | 95% |
3-Amino-3-phenylpropionic acid
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; acetone at 0℃; for 3h; |
benzaldehyde
N-(9-fluorenylmethoxycarbonyloxy)hydroxylamine
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium 2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-olate / ethyl acetate / 4 h / 40 °C / Inert atmosphere 2: acetic acid; zinc / tetrahydrofuran; water / 4 h / 40 °C / Inert atmosphere View Scheme |
N-(fluoren-9-ylmethoxycarbonyl)glycine
(4-ethylphenyl)isothiocyanate
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
Multistep reaction; | 95% |
trifluoroacetic acid
4-[5-(4-aminobutyl)thien-2-yl]butylamine
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
Multistep reaction.; | 73% |
2-fluoropyrimidine
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
C13H14N4O
Conditions | Yield |
---|---|
Stage #1: (±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine solid phase reaction; Stage #2: With piperidine In N,N-dimethyl-formamide solid phase reaction; Stage #3: 2-fluoropyrimidine Further stages; | 23% |
5-(9H-fluoren-9-ylmethoxycarbonyl)aminopentanoic acid
5-(9H-fluoren-9-ylmethoxy)-1,3,4-oxadiazol-2(3H)-one
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
Multistep reaction.; | 22 mg |
3-(9-fluorenylmethyloxycarbonyl)aminobenzoic acid
5-(9H-fluoren-9-ylmethoxy)-1,3,4-oxadiazol-2(3H)-one
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
Multistep reaction.; | 6 mg |
5-(9H-fluoren-9-ylmethoxy)-1,3,4-oxadiazol-2(3H)-one
5-[N-(4-methylpyridin-2-yl)amino]pentanoic acid
(±)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
Conditions | Yield |
---|---|
Multistep reaction.; | 17 mg |
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The CAS register number of Benzenepropanoic acid, b-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]- is 180181-93-5. It also can be called as Fmoc-3-amino-3-phenylpropionic acid and the systematic name about this chemical is 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-phenylpropanoic acid. The molecular formula about this chemical is C24H21NO4 and the molecular weight is 387.43.
Physical properties about Benzenepropanoic acid, b-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]- are: (1)ACD/LogP: 5.16; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 3.75; (4)ACD/LogD (pH 7.4): 1.99; (5)ACD/BCF (pH 5.5): 189.73; (6)ACD/BCF (pH 7.4): 3.34; (7)ACD/KOC (pH 5.5): 590.14; (8)ACD/KOC (pH 7.4): 10.4; (9)#H bond acceptors: 5; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 55.84 Å2; (13)Index of Refraction: 1.632; (14)Molar Refractivity: 108.44 cm3; (15)Molar Volume: 303.7 cm3; (16)Polarizability: 42.99x10-24cm3; (17)Surface Tension: 57.2 dyne/cm; (18)Density: 1.275 g/cm3; (19)Flash Point: 326.9 °C; (20)Enthalpy of Vaporization: 96.2 kJ/mol; (21)Boiling Point: 617 °C at 760 mmHg; (22)Vapour Pressure: 4.43E-16 mmHg at 25 °C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)CC(c1ccccc1)NC(=O)OCC4c2ccccc2c3c4cccc3
(2)InChI: InChI=1/C24H21NO4/c26-23(27)14-22(16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h1-13,21-22H,14-15H2,(H,25,28)(H,26,27)
(3)InChIKey: PTSLRPMRTOVHAB-UHFFFAOYAR
(4)Std. InChI: InChI=1S/C24H21NO4/c26-23(27)14-22(16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h1-13,21-22H,14-15H2,(H,25,28)(H,26,27)
(5)Std. InChIKey: PTSLRPMRTOVHAB-UHFFFAOYSA-N