Products Categories
CAS No.: | 191171-55-8 |
---|---|
Name: | 2-Aminophenylboronic acid pinacol ester |
Article Data: | 60 |
Molecular Structure: | |
Formula: | C12H18BNO2 |
Molecular Weight: | 219.091 |
Synonyms: | 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylamine;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; |
Density: | 1.05 g/cm3 |
Melting Point: | 63-68 °C(lit.) |
Boiling Point: | 335.6 °C at 760 mmHg |
Flash Point: | 156.8 °C |
Solubility: | insoluble in water |
Appearance: | cream crystalline powder |
Hazard Symbols: | Xn, Xi |
Risk Codes: | 36/37/38-20/21/22 |
Safety: | 26-36 |
PSA: | 44.48000 |
LogP: | 2.14920 |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide for 12h; Reflux; | 98% |
With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate In dimethyl sulfoxide at 85℃; for 12h; Inert atmosphere; | 87% |
With tris(trimethylphosphine)nickel(II) chloride; (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride In toluene at 100℃; for 1h; Inert atmosphere; | 84% |
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethyl acetate at 80℃; for 4h; Temperature; Solvent; Inert atmosphere; | 95.8% |
2-iodophenylamine
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With dichlorobis(chlorodi-tert-butylphosphine) palladium(II); triethylamine In toluene for 2h; Inert atmosphere; Reflux; | 95% |
With N(CH2CH3)3; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane (Ar); addn. of triethylamine, palladium compd. and borane deriv. to dioxane soln. of aniline deriv., heating at 100°C for 5 h; | 84% |
With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In further solvent(s) byproducts: C6H5NH2; (Ar); addn. of 2-IC6H4NH2 to suspn. of PdCl2(dppf) in 1-butyl-3-methylimidazolium tetrafluoroborate; stirring at 100°C; cooling to ambient temp., addn. of Et3N and then pinacolborane (2 equiv.); stirring at 100°C for 0.3 h; extn. with petroleum ether, removal of solvent; | 60% |
2-bromoaniline
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine In 1,4-dioxane at 100℃; for 12h; | 87% |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine In 1,4-dioxane Inert atmosphere; | 84% |
With triethylamine; CyJohnPhos; palladium diacetate In 1,4-dioxane at 80℃; for 1h; | 81% |
Conditions | Yield |
---|---|
With potassium phosphate tribasic heptahydrate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); XPhos In ethanol at 20℃; for 1h; | 84% |
With tris(trimethylphosphine)nickel(II) chloride; (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; | 80% |
With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; Sealed tube; | 80% |
With C52H67ClFeNPPd; potassium acetate In 1,4-dioxane at 110℃; for 3h; Suzuki-Miyaura coupling; Inert atmosphere; | 58% |
2,3-dimethyl-2,3-butane diol
2-aminophenylboronic acid
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
In tetrahydrofuran | 76% |
In tetrahydrofuran stirred under N2 overnight; evapn., chromy. (SiO2, EtOAc/toluene); | 76% |
2-iodophenylamine
bis(pinacol)diborane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With pyridine; C50H44CuN4OP2(1+)*F6P(1-); N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃; for 12h; Inert atmosphere; Irradiation; | 71% |
With bis-(dimethylamino)methane In water; acetone; acetonitrile at -5℃; for 0.25h; UV-irradiation; Flow reactor; chemoselective reaction; | 60% |
With caesium carbonate In methanol for 24h; Reflux; Inert atmosphere; | 37% |
With pyridine; cesium fluoride In dimethyl sulfoxide at 105℃; for 2h; Inert atmosphere; Schlenk technique; | 17% |
2,3-dimethyl-2,3-butane diol
Trimethyl borate
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
Stage #1: Trimethyl borate; 2-bis(trimethylsilyl)aminophenyl lithium In tetrahydrofuran at -70 - -60℃; Inert atmosphere; Stage #2: 2,3-dimethyl-2,3-butane diol In tetrahydrofuran; methanol at 20℃; | 52% |
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With hydrogenchloride In octane; water at 20℃; for 24h; Inert atmosphere; | 46% |
2-Chloroaniline
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
2-anilineboronic acid pinacol ester
Conditions | Yield |
---|---|
With triethylamine; CyJohnPhos; palladium diacetate In 1,4-dioxane at 100℃; for 2h; | 7% |
What can I do for you?
Get Best Price