Detail of "2260-50-6"

Reference

The desensitizing interaction of hexafluorenium with the cholinergic receptor in the diaphragm of the rat

The desensitizing interaction of hexafluorenium with the cholinergic receptor in the diaphragm of the rat. Scaf, A. H. J.; Langendijk, J. W. A. (Dep. Pharmacol., State Univ. Groningen, Groningen, Neth.). Arch. Int. Pharmacodyn. Ther., 225(2), 196-207 (English) 1977. CODEN: AIPTAK. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The interaction of hexafluorenium bromide (I) [317-52-2] with acetylcholine iodide [2260-50-6], carbachol [51-83-2] and suxamethonium chloride [71-27-2] with regard to the depolarization of the end-plate of rat diaphragm was studied. The depolarization was measured with the moving meniscus technique of Fatt. The competitive antagonist d-tubocurarine chloride [57-94-3] was included in the studies. I inhibited acetylcholinesterase [9000-81-1] in the end-plate. The receptors in the end-plate were desensitized by carbachol and suxamethonium. I enhanced the desensitization by suxamethonium. D-tubocurarine had no direct influence on desensitization. The desensitization of the receptors in rat diaphragm is compatible with a cyclic model of desensitization. The desensitizing interaction of I with the receptors may explain the non-competetive antagonism with depolarizing drugs with regard to the depolarization of the end-plate as well as the synergism with depolarizing drugs with regard to the paralysis of indirectly stimulated muscle. The affinities of carbachol, suxamethonium and d-tubocurarine to the sensitive receptors were 4.9, 5.2 and 6.8, resp.

Influence of oxytocin and meperidine on the isolated human umbilical artery

Influence of oxytocin and meperidine on the isolated human umbilical artery. Yao, Alice C.; Nergardh, Arne; Boreus, Lars O. (Dep. Pediatr., Karolinska Hosp., Stockholm, Swed.). Biol. Neonate, 29(5-6), 333-42 (English) 1976. CODEN: BNEOBV.Several substances with their cas registry numbers 50-13-5 and 971-74-4 may be metioned in this study. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 1 The influence of oxytocin [50-56-6] and meperidine-HCl (I) [50-13-5] on responses of the isolated human umbilical artery to acetylcholine iodide [2260-50-6] and(or) hydroxytryptamine creatinine sulfate [971-74-4] was investigated. Thirty-two prepns. from 21 normal full-term deliveries were utilized. A method of simultaneously measuring the resistance to flow and longitudinal tension in the perfused artery was a sensitive way to register functional responses. Oxytocin enhanced the response of the umbilical artery to acetylcholine and hydroxytryptamine whereas I blocked the constriction produced by hydroxytryptamine. Both these effects lasted from 30 min to >2 h and were reversible. .