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CAS No.: | 23056-29-3 |
---|---|
Name: | N-phenylpiperidin-4-amine |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C11H16 N2 |
Molecular Weight: | 176.261 |
Synonyms: | Piperidine,4-anilino- (8CI); 4-Anilinopiperidine; N-(Piperidin-4-yl)aniline;N-Phenylpiperidin-4-amine; NSC 80678 |
Density: | 1.052g/cm3 |
Boiling Point: | 312°Cat760mmHg |
Flash Point: | 185.3°C |
PSA: | 24.06000 |
LogP: | 2.25230 |
1-(tert-butoxycarbonyl)-4-phenylaminopiperidine
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 1h; | 100% |
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 3h; | 86% |
With trifluoroacetic acid In dichloromethane |
N-(1-ethoxycarbonyl-4-piperidinyl)aniline
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
With hydrogenchloride In water for 16h; Heating; | 92% |
4-aminopiperidine
chlorobenzene
A
1-phenylpiperidin-4-ylamine
C
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
With sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium(0) In xylene at 130℃; for 24h; | A 60% B 7% C n/a |
4-aminopiperidine
bromobenzene
A
1-phenylpiperidin-4-ylamine
C
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
With chiral ferrocene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) In xylene at 130℃; for 24h; Product distribution; Further Variations:; Reagents; | A 18% B 8% C 15% |
aniline
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) molecular sieves; 2) NaBH4 / 1) benzene, reflux, 20 h; 2) EtOH, room temp., 5 h 2: 92 percent / 6 N aq. HCl / H2O / 16 h / Heating View Scheme |
N-ethoxycarbonyl-4-piperidone
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) molecular sieves; 2) NaBH4 / 1) benzene, reflux, 20 h; 2) EtOH, room temp., 5 h 2: 92 percent / 6 N aq. HCl / H2O / 16 h / Heating View Scheme |
Conditions | Yield |
---|---|
Stage #1: 4-piperidone hydrochloride; aniline With acetic acid; zinc at 20 - 70℃; for 24h; Stage #2: With sodium hydroxide In water Product distribution / selectivity; Cooling with ice; |
N-tert-butyloxycarbonylpiperidin-4-one
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme |
aniline
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme |
4-piperidone hydrochloride
phenyl-piperidin-4-yl-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 24 h / 20 °C 2: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C 3: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme |
Molecular Structure of N-Phenyl-4-piperidinamine (CAS NO.23056-29-3):
IUPAC Name: N-phenylpiperidin-4-amine
Empirical Formula: C11H16N2
Molecular Weight: 176.2581
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 24.06 Å2
Index of Refraction: 1.579
Molar Refractivity: 55.634 cm3
Molar Volume: 167.427 cm3
Surface Tension: 42.068 dyne/cm
Density: 1.053 g/cm3
Flash Point: 185.298 °C
Enthalpy of Vaporization: 55.297 kJ/mol
Boiling Point: 312.012 °C at 760 mmHg
Vapour Pressure: 0.001 mmHg at 25°C
InChI
InChI=1/C11H16N2/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-5,11-13H,6-9H2
Smiles
N1CCC(Nc2ccccc2)CC1
HazardClass: Irritant
N-Phenyl-4-piperidinamine , with CAS number of 23056-29-3, can be called 4-piperidinamine, N-phenyl- ; N-phenylpiperidin-4-amine .