Detail of > 25316-40-9
- MSDS Download

- CAS Number:
- 25316-40-9
- Name:
Doxorubicin hydrochloride
- Formula:
- C27H30ClNO11
- Molecular Structure:

- Synonyms:
- 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S,10S)- (9CI);5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-;Adriamycin, hydrochloride (8CI);ADM hydrochloride;ADR;Adriablastina CS;Adriacin;Adriamycin;Adriblastin;Adriblastina;Adriblastina RD;DOX HCl;FI 106;FI 6804;Lipo-Dox;
- Molecular Weight:
- 580.03
- EINECS:
- 246-818-3
- Melting Point:
- 216 °C (dec.)(lit.)
- Boiling Point:
- 810.3 °C at 760 mmHg
- Flash Point:
- 443.8 °C
- Appearance:
- orange-red crystalline solid
- Hazard Symbols:
T,
T+- Risk Codes:
- 45-22-40-26/27/28
- Safety:
- 53-45-36/37/39-22-7/9Details
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Reference
- Increased sensitivity of canine sarcoma cells to lysis with alloantiserum and complement after pretreatment of cells with doxorubicin hydrochloride
- Increased sensitivity of canine sarcoma cells to lysis with alloantiserum and complement after pretreatment of cells with doxorubicin hydrochloride. Madewell, B. R.In this study, 50-76-0 and 59-05-2 are also used.; Grant, C. K. (Sch. Vet. Med., Univ. California, Davis, Calif., USA). Am. J. Vet. Res., 38(3), 333-5 (English) 1977. CODEN: AJVRAH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 15 The 51Cr release assay was used to detect lysis of canine sarcoma cells incubated in vitro with alloantiserum and complement. Preincubation of the target cells with the anti-cancer agent doxorubicin-HCl [25316-40-9] increased the sensitivity of the cells to antibody-mediated lysis. The effect was dependent upon drug dose and was not reproduced by treatment with methotrexate [59-05-2], cytarabine [147-94-4], or dactinomycin [50-76-0]. The observation suggests a possible ancillary mode of action for doxorubicin-HCl on neoplastic cells. .
- Studies on the stability of solid preparations for injection use after solubilization
- Studies on the stability of solid preparations for injection use after solubilization. 12. Mine, Masatoshi; Kiyofuji, Eiichi (Fac. Med., Kyushu Univ., Fukuoka, Japan). Gekkan Yakuji, 19(1), 167-73 (Japanese) 1977. CODEN: YAKUD5. 473-41-6 and 9002-07-7 which are cas registry numbers of chemicals are mentioned. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) After dissolving com. available solid injection prepns., the stability and properties of doxorubicin-HCl [25316-40-9], tridocelan [62154-08-9], trypsin [9002-07-7], Na tolbutamide [473-41-6], nitromin [302-70-5], Na nafcillin [985-16-0], and nicametate citrate [1641-74-3] are reported. .
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