Reference

Comparison between lumogallion and calcon on ion pair extraction-fluorometry and the application for determination of tertiary amines

Comparison between lumogallion and calcon on ion pair extraction-fluorometry and the application for determination of tertiary amines. Syoyama, Masatoshi; Sano, Toshiyuki (Crim. Sci. Lab., Nagoya 460, Japan). Yakugaku Zasshi, 104(4), 351-5 (Japanese) 1984. CODEN: YKKZAJ. ISSN: 0372-7750. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 4 A fluorometric method for the detn. of tertiary amine drugs is described. A CH2Cl2 soln. of lumogallion [4386-25-8] or calcon [2538-85-4] mixt. with the tertiary amine drugs was treated with MeOH and Al(NO3)3 soln. at 60° for ~10 min to form an Al complex, which was detd. at 564 nm with excitation at 488 nm (when lumogallion was used) or at 592 nm with excitation at 537 nm. The reagent formed a complex with tertiary amines, but not with primary amines. Concns. of 2 ′ 108-109 mol/mL carpipramine [5942-95-0], opipramol [315-72-0], benactyzine [302-40-9], chlorpromazine [50-53-3], procaine [59-46-1] and lidocaine [137-58-6] could be detd. Recoveries of added carpipramine and chlorpromazine were 99-103%. Primary and secondary amines at concns. lower than those of test compds. did not interfere with the detn. Reproducibility with a relative std. deviation of 2.6-6.6% was obsd. The method was in good agreement with the UV spectrophotometric method.

A simple extractive colorimetric determination of oxyfedrine hydrochloride in pharmaceuticals

A simple extractive colorimetric determination of oxyfedrine hydrochloride in pharmaceuticals. Sane, R. T.; Joshi, S. K.; Pandit, U. R.; Doshi, V. J.; Sawant, S. V.; Jukar, Swati; Nayak, V. G. (Ramnarain Ruia Coll., Matunga 400 019, India). Indian Drugs, 21(4), 165-6 (English) 1984. CODEN: INDRBA. ISSN: 0019-462X. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Oxyfedrine (I) [15687-41-9] is detd. in tablets by forming ion pairs with various dyes in acidic media, extg. with CHCl3, and measuring the absorbance. Recoveries were 99.3-100.15% and relative std. deviations were 1.23-1.92%. The dye used, absorbance max., and Beer's law concn. range were: bromocresol green [76-60-8], 420, 2-16; bromophenol blue [115-39-9] 420, 2-12; methyl orange [547-58-0] 420, 2-12; Eriochrome Black T [1787-61-7] 520, 1.6-11.2; Solochrome Dark Blue [2538-85-4] 520, 1.6-12.8; and Patton and Reeders indicator [3737-95-9] 580 nm, 4-20 mg/mL.