Detail of "28289-54-5"

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Neurotoxicity of the meperidine analog N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse

Neurotoxicity of the meperidine analog N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse. Hallman, Haakan; Olson, Lars; Jonsson, Goesta (Dep. Histol., Karolinska Inst., Stockholm S-104 01, Swed.). Eur. J. Pharmacol., 97(1-2), 133-6 (English) 1984. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 9 The effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (I) [28289-54-5] on central monomaine neurons in mice was investigated. I (2 ′ 10 mg/kg, i.v.) produced a rapid and long-lasting redn. (-30%) of striatal dopamine [51-61-6], whereas the dopamine levels were only transiently reduced in mesencephalon and frontal cortex. Homovanillic acid [306-08-1] and DOPAC [102-32-9] were initially reduced (-50 to -70%) in striatum; whereas a marked recovery was obsd. in the chronic stage. I also induced a long-term redn. of noradrenaline [51-41-2] in the striatum and frontal cortex whereas 5-HT [50-67-9] and 5-HIAA [54-16-0] levels were essentially unaltered.In this experiment, several chemicals are used like 54-16-0 and 51-61-6 The data indicate a neurotoxic action of I on both dopamine and noradrenaline nerve terminals in mouse brain. The results are discussed in light of the potential use of I as a denervation tool in Parkinsonism model. .

Melanin affinity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, an inducer of chronic parkinsonism in humans

Melanin affinity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, an inducer of chronic parkinsonism in humans. Lyden, Annika; Bondesson, Ulf; Larsson, Bengt S.; Lindquist, Nils Gunnar (Dep. Drugs, Natl. Board Health Welfare, Uppsala S-751 25, Swed.). Acta Pharmacol. Toxicol., 53(5), 429-32 (English) 1983. CODEN: APTOA6. ISSN: 0001-6683. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 14 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)(I) [28289-54-5] bound to both isolated beef eye and synthetic dopamine melanin in vitro. Curvilinear Scatchard plots were obsd. for both melanins, indicating that >1 binding class must be implicated. The data for the binding of MPTP to beef eye melanin could be fitted by the assumption of 2 classes of binding sites and to dopamine melanin by 3 classes of binding sites. Beef eye and dopamine melanin contained a small no. of binding sites with a high assocn. const. and a great no. of binding sites with a low assocn. const. The concordance between the assocn. consts. indicates a binding to identical sites on the 2 melanins. The total binding capacity of beef eye melanin (0.53 mmol/mg melanin) was ~2 times that of dopamine melanin (0.27 mmol/mg melanin).