Detail of "3148-73-0"

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CAS Number:
3148-73-0
Name:
Acetic acid,2-acetylhydrazide
Superlist Name:
Diacetyl hydrazine
Molecular Structure:
Formula:
C₄H₈N₂O₂
Molecular Weight:
116.12
Synonyms:
1,2-Diacetyl hydrazine;Hydrazine,1,2-diacetyl- (6CI,7CI,8CI);1,2-Diacetylhydrazine;N,N'-Diacetylhydrazine;NSC42939;
EINECS:
221-576-1
Density:
1.091g/cm³
Melting Point:
138-140 °C(lit.)
Boiling Point:
349.9 °C at 760 mmHg
Flash Point:
183.3 °C
Solubility:
Soluble in water
Appearance:
white crystalline powder
Hazard Symbols:
Xi
Risk Codes:
20/21/22-36/37/38
Safety:
26-36-37/39 Details

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Determination of hydrazine metabolites of isoniazid in human urine by gas chromatography: Determination of hydrazine metabolites of isoniazid in human urine by gas chromatography. Timbrell, John A.; Wright, James M.; Smith, Clare M. (Dep. Clin. Pharmacol., R. Postgrad. Med. Sch., London, Engl.There are some reagents like 54-85-3 is used in this study.). J. Chromatogr., 138(1), 165-72 (English) 1977. CODEN: JOCRAM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A method is described for the detn. of isoniazid (I) [54-85-3], acetylisoniazid [1078-38-2], acetylhydrazine [1068-57-1], diacetylhydrazine [3148-73-0], and hydrazine [302-01-2] in urine. I, acetylhydrazine and hydrazine are reacted in aq. soln. with p-chlorobenzaldehyde [104-88-1] to form hydrazones. Following the addn. of appropriate internal stds., these hydrazones are then extd. into an org. solvent and detd. by gas chromatog. using a nitrogen-sensitive detector. Acetylisoniazid and diacetylhydrazine are detd. similarly after hydrolysis to I and acetylhydrazine, resp. .

Effects of isoniazid and its metabolites on phenytoin biotransformation in isolated rat hepatocytes: Effects of isoniazid and its metabolites on phenytoin biotransformation in isolated rat hepatocytes. Noda, Hiroshi; Eto, Seiji; Minemoto, Masao; Noda, Atsuko; Ohno, Kohji (Sch. Med., Univ. Occup. Environ. Health, Kitakyushu 807, Japan). Chem. Pharm.There are some reagents with their cas registry numbers 100-63-0 and 613-94-5 are used in this study. Bull., 35(1), 277-81 (English) 1987. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The inhibitory effects of isoniazid [54-85-3], its metabolites and related compds. on phenytoin [57-41-0] biotransformation was studied in an isolated rat hepatocyte system. Oxidn. of phenytoin was inhibited strongly by isoniazid, acetylhydrazine [1068-57-1], benzoylhydrazine [613-94-5], and phenylhydrazine [100-63-0], and weakly (but significantly) by acetylisoniazid [1078-38-2] and hydrazine [302-01-2]. Isonicotinic acid [55-22-1] and diacetylhydrazine [3148-73-0] had no effect. These observations may indicate that active hydrazine compds. are ones which can give a relatively significant rise to reactive intermediates such as radicals, diazene compds. or their relatives during the oxidn. metab. On the other hand, glucuronidation of the oxidized metabolite, 5-phenyl-5-(p-hydroxyphenyl)hydantoin [2784-27-2], was not affected by isoniazid. .