Detail of > 317-34-0
- CAS Number:
- 317-34-0
- Name:
Aminophylline
- Formula:
- 2(C7H8N4O2).C2H8N2
- Molecular Structure:
- Synonyms:
- Theodrox;Teofyllamin;component of Quinamm;Lasodex;Theophylline, compd. with ethylenediamine (2:1);Ammophyllin;Theophyldine;Diophllin;Prestwick_93;Diaphylline;Ethylenediamine, compd. with theophylline (1:2);Theophylline compound with ethylenediamine;Aminophylline (USP);Metaphyllin;Norofilina;Somophyllin O;Peterphyllin;Theophyllamine;Tefamin;1H-Purine-2,6-dione, 3,7-dihydro-1, 3-dimethyl-, compd. with 1,2-ethanediamine (2:1);Phyllocontin;1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine;Cardiofilina;Somophyllin;Cidophylline;Stenovasan;Dura-Tab S.M. Aminophylline;1,3-dimethyl-7H-purine-2,6-dione;Inophylline;Cardophylin;Theophyline ethylenediamine;Aminophyllin;Carena;Genophyllin;Syntophyllin;Theophyllin ethylenediamine;Ethophylline;Variaphylline;Vasofilina;Lixaminol;Theophylline ethylenediamine;Aminocardol;Neophyiline;Aminodur;Theolamine;Theolone;Linampheta;Theophylline ethylenediamine (TN);Aminofilina;Somophyllin (TN);Carine;Cardiomin;Phylcardin;Miofilin;1H-Purine-2,6-dione,3,7-dihydro-1,3- dimethyl-,compounds,compd. with 1,2-ethanediamine (2:1);Phyllindon;Grifomin;Minaphil;Euphyllin;Theophyllaminum;Aminophylline Anhydrous;Aminophlline Anhudrous;Rectalad-aminophylline;
- Molecular Weight:
- 420.43
- EINECS:
- 206-264-5
- Melting Point:
- 269-270 °C
- Boiling Point:
- 454.1 °C at 760 mmHg
- Flash Point:
- 228.4 °C
- Solubility:
- Soluble in water, insoluble in ethanol or ether
- Appearance:
- white to slightly yellowish powder
- Hazard Symbols:
Xn, 
C- Risk Codes:
- 22-42/43-34-36/37/38-20/21/22
- Safety:
- 45-36/37/39-26-23-36Details
- Transport Information:
- UN 2811 6.1/PG 3
- particular:
- particular
- Deleted CAS:
- 80186-94-3|8013-40-9|442519-87-1|12767-26-9
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Reference
- Characteristics of the response of different vessels to myotropic and neurotropic drugs in experimental hypertension
- Characteristics of the response of different vessels to myotropic and neurotropic drugs in experimental hypertension. Abdullina, R. N. (Bashk. Med. Inst., Ufa, USSR). Vopr. Reakt. Org. Norme Patol., Mater. Nauchn. Konf., 8-9. Edited by: Lotsmanov, Yu. A. Bashk. Med. Inst.: Ufa, USSR. (Russian) 1974. CODEN: 36CPA4. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) In dogs with exptl. renal hypertension, the resistance of highly toned blood vessels of the hindlimb was decreased by the myotropics, papaverine [58-74-2] (1 mg/kg), No-Spa [14009-24-6] (1 mg/kg), and euphyllin [317-34-0] (3 mg/kg), to a lesser extent than that of the low-toned blood vessels of the brain. The neurotropics, reserpine [50-55-5], benzohexonium [971-60-8], and methylanogalanthamine [18126-83-5], decreased perfusion pressure in hindimb to a greater extent than in brain vessels. Caroted arch denervation increased the effect of myotropics on hindlimb but not brain vessels.
- Theophylline disposition in patients with hepatic cirrhosis
- Theophylline disposition in patients with hepatic cirrhosis. Piafsky, Kenneth M.; Sitar, Daniel S.; Rangno, Robert E.; Ogilvie, Richard I. (Clin. Pharmacol. Div., Montreal Gen. Hosp., Montreal, Que., Can.). N. Engl. J. Med., 296(26), 1495-7 (English) 1977. CODEN: NEJMAG. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Patients with cirrhosis given single i.v. doses of theophylline ethylenediamine (I ethylenediamine) [317-34-0] had a prolonged plasma half-life (mean, 25.6 h vs. 6.7 h in controls) and a decreased plasma clearance (mean, 0.042 L/kg/h vs. 0.062 L/kg/h). Vols. of distribution of I in the cirrhotic patients did not substantially differ from normal. Plasma I binding in patients with cirrhosis averaged 36.8% as compared with 52.6% in normal subjects. There was no correlation between any lab. test of liver function and the plasma I half-life, except for serum albumin. The variable capacity to eliminate I precludes the use of usual maintenance dose schedules for bronchodilation in cirrhosis.
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