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| CAS No.: | 3430-26-0 |
|---|---|
| Name: | 2,5-Dibromo-4-methylpyridine |
| Article Data: | 4 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H5Br2N |
| Molecular Weight: | 250.92 |
| Synonyms: | 2,5-Dibromo-4-methylpyridine; |
| EINECS: | -0 |
| Density: | 1.911 g/cm3 |
| Melting Point: | 37-41 °C |
| Boiling Point: | 262.8 °C at 760 mmHg |
| Flash Point: | 112.7 °C |
| Appearance: | light yellow to orange low melting solid |
| Hazard Symbols: |
 Xn,  Xi
|
| Risk Codes: | 36/37/38-20/21/22 |
| Safety: | 36/37/39-26 |
| PSA: | 12.89000 |
| LogP: | 2.91500 |
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- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
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- 50288-62-5threo-Phenyl-2-piperidyl acetamide
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- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
| Conditions | Yield |
|---|---|
| Stage #1: 2,5-dibromopyridine With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.166667h; Stage #2: methyl iodide In tetrahydrofuran for 0.5h; | 86% |
- 98198-48-2
2-amino-5-bromo-4-methylpyridine
- 3430-26-0
2,5-Dibromo-4-methylpyridine
| Conditions | Yield |
|---|---|
| Stage #1: 2-amino-5-bromo-4-methylpyridine With hydrogen bromide; bromine; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: With sodium hydroxide In water at 20℃; pH=~ 13; | 68% |
| Stage #1: 2-amino-5-bromo-4-methylpyridine With hydrogen bromide; bromine; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: With sodium hydroxide In water pH=~ 13; | 68% |
- 557-21-1
zinc(II) cyanide
- 3430-26-0
2,5-Dibromo-4-methylpyridine
- 886364-86-9
5-bromo-4-methyl-pyridine-2-carbonitrile
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 150℃; for 0.0833333h; Negishi Coupling; Microwave irradiation; regioselective reaction; | 100% |
- 3430-26-0
2,5-Dibromo-4-methylpyridine
- 1122090-37-2
5-bromo-4-methyl-2-vinyl-pyridine
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water at 80℃; for 15h; Suzuki Coupling; Inert atmosphere; | 99% |
| With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 80℃; for 15h; Suzuki Coupling; | |
| With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 80℃; for 15h; Inert atmosphere; |
- 3430-26-0
2,5-Dibromo-4-methylpyridine
- 21655-48-1, 1013625-96-1
cis-2,6-dimethylpiperazine
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 110℃; for 18h; | 96% |
- 3430-26-0
2,5-Dibromo-4-methylpyridine
- 141-52-6
sodium ethanolate
- 610279-04-4
5-bromo-2-ethoxy-4-methylpyridine
| Conditions | Yield |
|---|---|
| In 1-methyl-pyrrolidin-2-one at 40 - 70℃; for 2h; Time; | 95% |
| Conditions | Yield |
|---|---|
| With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate monohydrate In water; toluene for 16h; Inert atmosphere; Reflux; | 93.3% |
- 4318-42-7
1-(1-methylethyl)piperazine
- 3430-26-0
2,5-Dibromo-4-methylpyridine
- 919496-46-1
1-(5-bromo-4-methylpyridin-2-yl)-3-isopropyl-piperazine
| Conditions | Yield |
|---|---|
| With pyridine for 5h; Heating / reflux; | 90% |
- 3430-26-0
2,5-Dibromo-4-methylpyridine
- 98-80-6
phenylboronic acid
- 31686-64-3
5-bromo-4-methyl-2-phenylpyridine
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water at 90℃; for 12h; Inert atmosphere; | 90% |
| With palladium diacetate; potassium carbonate; triphenylphosphine In methanol; acetonitrile at 50℃; for 24h; Suzuki Coupling; Inert atmosphere; regioselective reaction; | 82% |
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water Reflux; | 77% |
| Conditions | Yield |
|---|---|
| With copper(l) iodide; palladium(II) trifluoroacetate; palladium diacetate; diisopropylamine In methanol; acetonitrile for 24h; Reflux; Inert atmosphere; regioselective reaction; | 90% |
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Chemistry
Molecular structure of 2,5-Dibromo-4-picoline (CAS NO.3430-26-0) is:
Product Name: 2,5-Dibromo-4-picoline
CAS Registry Number: 3430-26-0
IUPAC Name: 2,5-dibromo-4-methylpyridine
Molecular Weight: 250.9186 [g/mol]
Molecular Formula: C6H5Br2N
XLogP3-AA: 2.9
H-Bond Donor: 0
H-Bond Acceptor: 1
Melting Point: 37-41 °C
Surface Tension: 44.9 dyne/cm
Density: 1.911 g/cm3
Flash Point: 112.7 °C
Enthalpy of Vaporization: 48.04 kJ/mol
Boiling Point: 262.8 °C at 760 mmHg
Vapour Pressure: 0.0174 mmHg at 25°C
Product Categories: blocks;Bromides;Pyridines;Pyridine;Pyridine Series;Halides;Boronic Acid;Brominated heterocyclic series
Uses
2,5-Dibromo-4-picoline (CAS NO.3430-26-0) is commonly used as pharmaceutical intermediate.
Safety Profile
Safty information about 2,5-Dibromo-4-picoline (CAS NO.3430-26-0) is:
Hazard Codes: 
Xn,Xi
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36/37/39-26
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Note: Harmful
HazardClass: IRRITANT
Specification
2,5-Dibromo-4-picoline , its cas register number is 3430-26-0. It also can be called 2,5-Dibromo-4-methylpyridine .It is a light yellow to orange low melting solid.