Reference

An efficient synthesis of 5-bromopyridine-2-carbonitrile

An efficient synthesis of 5-bromopyridine-2-carbonitrile. Markevitch, David Y.; Rapta, Miroslav; Hecker, Scott J.; Renau, Thomas E. (Essential Therapeutics Inc., CA, USA). Synthetic Communications, 33(19), 3285-3289 (English) 2003 Marcel Dekker, Inc. 97483-77-7 and 624-28-2 which are cas registry numbers of chemicals are mentioned. CODEN: SYNCAV. ISSN: 0039-7911. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) 5-Bromopyridine-2-carbonitrile was efficiently synthesized in two steps from 2,5-dibromopyridine with an overall yield of 75%. .

Preparation of 2-aryl-5-halopyridine derivatives

Preparation of 2-aryl-5-halopyridine derivatives. Watanabe, Tetsuya; Sato, Masahiro (Sanyo Chemical Industries, Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 03255074 A2 13 Nov 1991 Heisei, 14 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: C07D213-61. APPLICATION: JP 90-52520 2 Mar 1990. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 25, 75 The title derivs. I [R = C1-18 alkyl; X = Cl, Br, iodo; A = (F- or Cl-substituted) 1,4-phenylene, 4,4'-biphenylene; Y = O, S, CYC, direct bond; when Y is direct bond, A is 1,4-phenylene], useful as intermediates for liq. crystals, are prepd. Thus, 25.0 g p-IC6H4OH was treated with 17.8 g 1-bromohexane in DMSO in the presence of aq. NaOH to give 31.0 g p-hexyloxyiodobenzene (II). Then, 120 mL Et2O soln. of Grignard reagent prepd. from 15.There are some commonly used reagents with their cas registry numbers 624-28-2 and 111-25-1 in this article.0 g II and Mg was treated with 14.0 g 2,5-dibromopyridine in THF in the presence of dichlorobisdiphenylphosphinobutane palladium at room temp. under N atm. for 5 h to give 8.9 g I (X = Br, A = 1,4-phenylene, Y = direct bond, R = hexyl). .