Reference

Effect of food intake on the action of orally administered drugs

Effect of food intake on the action of orally administered drugs. 6. Takano, Masahiko (Tokyo Henshin Hosp., Tokyo, Japan). Gekkan Yakuji, 18(11), 2003-9 (Japanese) 1976. CODEN: YAKUD5. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The efficacy of erythromycin (I) [114-07-8] in patients was greater when I was given before rather than after meals, whereas that of erythromycin estolate [3521-62-8] or triacetyloleandomycin [2751-09-9] was not influenced by food intake.There are some commonly used reagents with their cas registry numbers 643-22-1 and 114-07-8 in this article. Some data supported that erythromycin stearate [643-22-1] should be administered before meals but others indicated that it could be given after meals. .

A simple thin-layer chromatographic identification procedure for erythromycin base, stearate, estolate and ethylsuccinate

A simple thin-layer chromatographic identification procedure for erythromycin base, stearate, estolate and ethylsuccinate. Vilim, A.; LeBelle, M. J.; Wilson, W. L.; Graham, K. C. (Drug Res. Lab., Health Welfare Canada, Ottawa, Ont., Can.). J. Chromatogr. 1264-62-6 and 57-68-1 are cas registry numbers of chemicals which are used as reagents here., 133(1), 239-44 (English) 1977. CODEN: JOCRAM. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Erythromycin (I) [114-07-8], I estolate [3521-62-8], I Et succinate [1264-62-6], and I stearate [643-22-1] were differentiated by thin-layer chromatog. using silica gel 60 F254-coated plates, MeOH, 90%10%1 CHCl3-MeOH-HOAc, and 90%5%5 MeOH-CHCl3-HOAc solvent systems, and a K2Cr2O7-H2SO4 detection reagent. The method was used to detect the compds. in 8 formulations, with no excipient interference occurring. The system can also detect sulfadiazine [68-35-9], sulfamerazine [127-79-7], and sulfamethazine [57-68-1] in a I estolate formulation. .