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Basic Information
CAS No.: 35421-08-0
Name: 4-Hydroxybenzyl chloride
Article Data: 9
Molecular Structure:
Molecular Structure of 35421-08-0 (4-Hydroxybenzyl chloride)
Formula: C7H7 Cl O
Molecular Weight: 142.585
Synonyms: 4-Chloromethylphenol;4-Hydroxybenzyl chloride; p-Chloromethylphenol; p-Hydroxybenzyl chloride; a-Chloro-p-cresol
Density: 1.233g/cm3
Boiling Point: 257.4°Cat760mmHg
Flash Point: 109.5°C
PSA: 20.23000
LogP: 2.13100
Synthetic route
169308-96-7

4-tosyloxy-benzylchloride

35421-08-0

4-hydroxybenzyl chloride

Conditions
ConditionsYield
With potassium fluoride on basic alumina for 0.05h; Substitution; microwave irradiation;83%
39720-27-9

4-acetoxybenzyl chloride

35421-08-0

4-hydroxybenzyl chloride

Conditions
ConditionsYield
With sodium perborate In methanol at 25℃; for 0.5h;81%
623-05-2

(4-hydroxyphenyl)methanol

35421-08-0

4-hydroxybenzyl chloride

Conditions
ConditionsYield
With tetrachloromethane; potassium fluoride; triphenylphosphine In N,N-dimethyl-formamide at 50℃; for 0.0833333h; Microwave irradiation;81%
With thionyl chloride In chloroform at 20℃; for 1h;48%
With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In chloroform at 20℃; Inert atmosphere;
67-56-1

methanol

61661-14-1

-chlorid

35421-08-0

4-hydroxybenzyl chloride

106-44-5

p-cresol

n-C3H7X

n-C3H7X

35421-08-0

4-hydroxybenzyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: PCl3, PhCONH2, (PhCO)2O2, SO2Cl2 / 135 °C
View Scheme
15451-04-4

p-chloromethyl-phenyl chloroformate

35421-08-0

4-hydroxybenzyl chloride

937-62-2

p-tolyl chloroformate

35421-08-0

4-hydroxybenzyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PCl3, PhCONH2, (PhCO)2O2, SO2Cl2 / 135 °C
View Scheme
15451-04-4

p-chloromethyl-phenyl chloroformate

68-12-2, 33513-42-7

N,N-dimethyl-formamide

35421-08-0

4-hydroxybenzyl chloride

Conditions
ConditionsYield
In methanol; acetonitrile
In methanol; acetonitrile
35421-08-0

4-hydroxybenzyl chloride

86087-23-2

(S)-3-hydroxytetyrahydrofurane

(3S)-3-[p-(chloromethyl)phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Stage #1: 4-hydroxybenzyl chloride In dichloromethane at -5 - 0℃; for 3h;
Stage #2: (S)-3-hydroxytetyrahydrofurane With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4.5h; Reagent/catalyst; Reflux;
95.3%
35421-08-0

4-hydroxybenzyl chloride

A

4-methylphosphonomethyl phenol

B

3173-38-4

diethyl (4-hydroxybenzyl)phosphonate

Conditions
ConditionsYield
In acetonitrileA n/a
B 93%
In acetonitrileA 93%
B n/a
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  • 4-Hydroxybenzyl chloride CAS No.35421-08-0

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    4-Hydroxybenzyl chloride CAS No.35421-08-0

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  • 4-Hydroxybenzyl chloride

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Chemistry

IUPAC Name: 4-Hydroxybenzyl chloride
The MF of 4-Hydroxybenzyl chloride (35421-08-0) is C7H7ClO.

                              
The MW of 4-Hydroxybenzyl chloride (35421-08-0) is 142.58.
Synonyms of 4-Hydroxybenzyl chloride (35421-08-0): p-Choro-m-cresol ; p-Hydroxybenzylchloride ; 4-Chloromethylphenol ; 4-Hydroxybenzyl chloride
Index of Refraction: 1.569 
Density: 1.233 g/ml 
Flash Point: 109.5 °C
Boiling Point: 257.4 °C

Uses

  4-Hydroxybenzyl chloride (35421-08-0) is used as pharmaceutical intermediates.