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CAS No.: | 35421-08-0 |
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Name: | 4-Hydroxybenzyl chloride |
Article Data: | 9 |
Molecular Structure: | |
Formula: | C7H7 Cl O |
Molecular Weight: | 142.585 |
Synonyms: | 4-Chloromethylphenol;4-Hydroxybenzyl chloride; p-Chloromethylphenol; p-Hydroxybenzyl chloride; a-Chloro-p-cresol |
Density: | 1.233g/cm3 |
Boiling Point: | 257.4°Cat760mmHg |
Flash Point: | 109.5°C |
PSA: | 20.23000 |
LogP: | 2.13100 |
4-tosyloxy-benzylchloride
4-hydroxybenzyl chloride
Conditions | Yield |
---|---|
With potassium fluoride on basic alumina for 0.05h; Substitution; microwave irradiation; | 83% |
4-acetoxybenzyl chloride
4-hydroxybenzyl chloride
Conditions | Yield |
---|---|
With sodium perborate In methanol at 25℃; for 0.5h; | 81% |
(4-hydroxyphenyl)methanol
4-hydroxybenzyl chloride
Conditions | Yield |
---|---|
With tetrachloromethane; potassium fluoride; triphenylphosphine In N,N-dimethyl-formamide at 50℃; for 0.0833333h; Microwave irradiation; | 81% |
With thionyl chloride In chloroform at 20℃; for 1h; | 48% |
With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In chloroform at 20℃; Inert atmosphere; |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 2: PCl3, PhCONH2, (PhCO)2O2, SO2Cl2 / 135 °C View Scheme |
p-chloromethyl-phenyl chloroformate
4-hydroxybenzyl chloride
p-tolyl chloroformate
4-hydroxybenzyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: PCl3, PhCONH2, (PhCO)2O2, SO2Cl2 / 135 °C View Scheme |
p-chloromethyl-phenyl chloroformate
N,N-dimethyl-formamide
4-hydroxybenzyl chloride
Conditions | Yield |
---|---|
In methanol; acetonitrile | |
In methanol; acetonitrile |
4-hydroxybenzyl chloride
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: 4-hydroxybenzyl chloride In dichloromethane at -5 - 0℃; for 3h; Stage #2: (S)-3-hydroxytetyrahydrofurane With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4.5h; Reagent/catalyst; Reflux; | 95.3% |
4-hydroxybenzyl chloride
B
diethyl (4-hydroxybenzyl)phosphonate
Conditions | Yield |
---|---|
In acetonitrile | A n/a B 93% |
In acetonitrile | A 93% B n/a |
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IUPAC Name: 4-Hydroxybenzyl chloride
The MF of 4-Hydroxybenzyl chloride (35421-08-0) is C7H7ClO.
The MW of 4-Hydroxybenzyl chloride (35421-08-0) is 142.58.
Synonyms of 4-Hydroxybenzyl chloride (35421-08-0): p-Choro-m-cresol ; p-Hydroxybenzylchloride ; 4-Chloromethylphenol ; 4-Hydroxybenzyl chloride
Index of Refraction: 1.569
Density: 1.233 g/ml
Flash Point: 109.5 °C
Boiling Point: 257.4 °C
4-Hydroxybenzyl chloride (35421-08-0) is used as pharmaceutical intermediates.