Detail of "3731-52-0"

CAS Number:
3731-52-0
Name:
3-(Aminomethyl)pyridine
Molecular Structure:
Formula:
C₆H₈N₂
Molecular Weight:
108.14
Synonyms:
3-Aminomethylpyridine;2-Aminomethyl pyridine;Pyridine, 3- (aminomethyl)-;Picolaminum [INN-Latin];pyridin-3-ylmethanamine;3-Pyridinemethanamine;Picolamine;Picolamine [DCF:INN];3-Picolylamine;3-Pyridylmethylamine;Pyridine, 3-(aminomethyl)- (8CI);Picolamina [INN-Spanish];pyridin-3-ylmethylazanium;1-pyridin-3-ylmethanamine;3-Pyridinemethylamine;
EINECS:
223-091-0
Density:
1.053 g/cm³
Melting Point:
-21 °C(lit.)
Boiling Point:
226 °C at 760 mmHg
Flash Point:
100.6 °C
Solubility:
Freely soluble in water
Appearance:
Clear colourless to slighly yellow liquid
Hazard Symbols:
C, Xi
Risk Codes:
Statements 34-37-36/37/38
Safety:
26-36/37/39-45-25-36 Details
Transport Information:
UN 2735 8/PG 2

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3-Pyridylmethyl aryl urea rodenticides: Kilbourn, Edward E.Some chemicals with cas registry numbers like 53558-25-1 are also used.; Peardon, David L.; Ware, J. Edgar (Rohm and Haas Co., USA). U.S. US 3994905 30 Nov 1976, 7 pp. Division of U.S. 3,931,203. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07D213-75. NCL: 260294800F. APPLICATION: US 73-342334 19 Mar 1973. DOCUMENT TYPE: Patent CA Section: 5 (Agrochemicals) Section cross-reference(s): 25, 27 The title compds. I (Ar = 4-substituted phenyl or -naphthyl) and their acid addn. salts are rodenticides. Thus, 1-(3-pyridylmethyl)-3-(4-nitrophenyl)urea [53558-25-1] prepd. from p-nitrophenyl isocyanate [100-28-7] and 3-(aminomethyl)pyridine [3731-52-0] given orally to albino rate at 50 mg/kg was 100% effective; addnl. 28 I were prepd. and tested. .

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential: Tanaka, Rieko; Rubio, Almudena; Harn, Nancy K.; Gernert, Douglas; Grese, Timothy A.; Eishima, Jun; Hara, Mitsunobu; Yoda, Nobuyuki; Ohashi, Rui; Kuwabara, Takashi; Soga, Shiro; Akinaga, Shiro; Nara, Shinji; Kanda, Yutaka (Pharmaceutical Research Center, Kyowa Hakko Kogyo Co. Ltd, Shizuoka 411-8731, Japan). Bioorganic & Medicinal Chemistry, 15(3), 1363-1382 (English) 2007 Elsevier Ltd. 923002-65-7 and 3731-52-0 are cas registry numbers. These chemicals are also mentioned in this article. CODEN: BMECEP. ISSN: 0968-0896. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 7, 27 The design and synthesis of a novel piperidine series of farnesyltransferase (FTase) inhibitors with reduced potential for metabolic glucuronidation are described. The various substitution and exchange of the Ph group at the C-2 position of the previously described 2-(4-hydroxy)phenyl-3-nitropiperidine 1a (I) (FTase IC50 = 5.4 nM) resulted in metabolically stable compds. with potent FTase inhibition (14a IC50 = 4.3 nM, 20a IC50 = 3.0 nM, and 50a IC50 = 16 nM). Mol. modeling studies of these compds. complexed with FTase and farnesyl pyrophosphate are also described. .