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Basic Information
| CAS No.: | 4269-17-4 |
|---|---|
| Name: | 4-Bromo-9H-fluoren-9-one |
| Article Data: | 22 |
| Molecular Structure: | |
|
|
|
| Formula: | C13H7BrO |
| Molecular Weight: | 259.102 |
| Synonyms: | 4-bromo-fluoren-9-one;4-Brom-fluoren-9-on;4-bromo-9h-fluoren-9-one;4-bromofluorenone;4-Bromfluorenon; |
| Density: | 1.609g/cm3 |
| Melting Point: | 127.0 to 131.0 °C |
| Boiling Point: | 392.8°Cat760mmHg |
| Flash Point: | 131.3°C |
| PSA: | 17.07000 |
| LogP: | 3.66050 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: bromobenzene In dichloromethane at 5℃; for 0.5h; Stage #2: 3-Bromopropionyl chloride In dichloromethane at 5 - 20℃; for 16h; Stage #3: With trifluorormethanesulfonic acid In dichloromethane at 90℃; for 4h; Temperature; Reagent/catalyst; | 88.5% |
- 54245-41-9
2'-bromo-[1,1'-biphenyl]-2-carbonitrile
- 4269-17-4
4-bromo-9H-fluorene-9-one
Conditions
| Conditions | Yield |
|---|---|
| With sulfuric acid; acetic acid for 12h; Reflux; | 80% |
| With dichloro bis(acetonitrile) palladium(II); water; silver trifluoroacetate In N,N-dimethyl acetamide; trifluoroacetic acid at 140℃; for 72h; Heck Reaction; Glovebox; Inert atmosphere; | 57% |
| With sulfuric acid |
- 690260-87-8
ethyl 2’-bromo-[1,1’-biphenyl]-2-carboxylate
- 4269-17-4
4-bromo-9H-fluorene-9-one
Conditions
| Conditions | Yield |
|---|---|
| With methanesulfonic acid at 100℃; for 14h; | 61% |
Conditions
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide; sulfuric acid In dichloromethane at 20℃; for 12h; | 47.9% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: (S)-2-(3-bromo-2-iodophenyl)-4-isopropyl-4,5-dihydrooxazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; Stage #2: 1-Bromo-2-iodobenzene In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Stage #3: With n-butyllithium In tetrahydrofuran; hexane at -78 - 25℃; for 12h; Inert atmosphere; diastereoselective reaction; | A 20% B 46% |
| Stage #1: (S)-2-(3-bromo-2-iodophenyl)-4-isopropyl-4,5-dihydrooxazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: 1-Bromo-2-iodobenzene In tetrahydrofuran; hexane at -78℃; for 12h; Overall yield = 46 %; Overall yield = 234 mg; diastereoselective reaction; | A n/a B n/a |
...Expand
- 98-01-1
furfural
- 39655-12-4
2-bromo-2’-iodo-1,1’-biphenyl
A
- 486-25-9
9-fluorenone
B
- 4269-17-4
4-bromo-9H-fluorene-9-one
Conditions
| Conditions | Yield |
|---|---|
| With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,3-bis-(diphenylphosphino)propane; sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; for 48h; Inert atmosphere; | A 18% B 31% |
...Expand
- 19459-33-7
4-bromo-9H-fluorene
- 4269-17-4
4-bromo-9H-fluorene-9-one
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen bromide Diazotization.Erhitzen mit CuBr und wss. HBr; |
- 4269-17-4
4-bromo-9H-fluorene-9-one
- 16149-47-6
4-Brom-1-amino-fluorenon-(9)
- 4269-17-4
4-bromo-9H-fluorene-9-one
Conditions
| Conditions | Yield |
|---|---|
| (i) NaNO2, aq. HCl, (ii) H3PO2; Multistep reaction; |
