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| CAS No.: | 452-77-7 |
|---|---|
| Name: | 3-Fluoro-4-methylaniline |
| Article Data: | 17 |
| Molecular Structure: | |
|
|
|
| Formula: | C7H8FN |
| Molecular Weight: | 125.146 |
| Synonyms: | p-Toluidine,3-fluoro- (6CI,7CI,8CI);(3-Fluoro-4-methylphenyl)amine;2-Fluoro-4-aminotoluene;3-Fluoro-p-toluidine;4-Amino-2-fluorotoluene;NSC 57470; |
| EINECS: | 207-212-4 |
| Density: | 1.115 g/cm3 |
| Melting Point: | 30-32 °C |
| Boiling Point: | 203.8 °C at 760 mmHg |
| Flash Point: | 88.9 °C |
| Appearance: | clear pale yellow to brownish liquid after melting |
| Hazard Symbols: |
 T,  Xi,  Xn
|
| Risk Codes: | 36/37/38-23/24/25-20/21/22 |
| Safety: | 45-36/37/39-26-36/37-36 |
| Transport Information: | UN 2811 |
| PSA: | 26.02000 |
| LogP: | 2.29750 |
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| Conditions | Yield |
|---|---|
| With ammonium chloride; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; zinc In water at 20℃; for 7h; | 93% |
| With indium (III) iodide; 1,1,3,3-Tetramethyldisiloxane In toluene at 60℃; for 6h; Inert atmosphere; Sealed tube; chemoselective reaction; | 74% |
| With ethanol; platinum Hydrogenation; |
| Conditions | Yield |
|---|---|
| aluminum nickel In ethanol |
| Conditions | Yield |
|---|---|
| Stage #1: 4-chloro-2-fluorotoluene With [(k2-P,N-di(1-adamantyl)-2-morpholinophenylphosphine)Pd(Ph)Cl]; sodium t-butanolate In 1,4-dioxane Inert atmosphere; Glovebox; Stage #2: With ammonia In 1,4-dioxane at 24℃; Inert atmosphere; Glovebox; | 62% |
| With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; ammonia; sodium t-butanolate In 1,4-dioxane at 65℃; for 20h; Inert atmosphere; chemoselective reaction; | 61% |
- 372-19-0
meta-fluoroaniline
- 593-53-3
Methyl fluoride
A
- 443-86-7
3-fluoro-2-methylaniline
B
- 367-29-3
3-fluoro-6-methylaniline
C
- 452-77-7
3-fluoro-4-methyl-phenylamine
| Conditions | Yield |
|---|---|
| With oxygen; trimethylamine In gaseous matrix at 80℃; Irradiation; | A 56 % Spectr. B 25 % Spectr. C 19 % Spectr. |
| Conditions | Yield |
|---|---|
| With trifluorormethanesulfonic acid; fluorine at 20℃; Title compound not separated from byproducts; |
- 452-77-7
3-fluoro-4-methyl-phenylamine
- 202865-78-9
2-bromo-5-fluoro 4-methylaniline
| Conditions | Yield |
|---|---|
| With bromine; potassium carbonate In dichloromethane at -15℃; for 1h; | 100% |
| With bromine; potassium carbonate In dichloromethane at -15℃; for 1h; | 100% |
| With bromine; potassium carbonate In dichloromethane at -15℃; for 1h; | 100% |
- 452-77-7
3-fluoro-4-methyl-phenylamine
- 333-20-0
potassium thioacyanate
- 1155287-47-0
5-fluoro-6-methylbenzo[d]thiazol-2-amine
| Conditions | Yield |
|---|---|
| With acetic acid at 20℃; for 3h; | 99% |
| Stage #1: 3-fluoro-4-methyl-phenylamine; potassium thioacyanate With bromine; acetic acid at 20℃; for 20.33h; Stage #2: With ammonia In water for 2h; pH=8; | 98% |
| Conditions | Yield |
|---|---|
| With sulfuric acid at 170 - 175℃; for 1h; | 98% |
- 452-77-7
3-fluoro-4-methyl-phenylamine
| Conditions | Yield |
|---|---|
| Stage #1: C11H8FN With (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate at -20℃; for 0.25h; Michael Addition; Sealed tube; Inert atmosphere; Stage #2: 3-fluoro-4-methyl-phenylamine at -20℃; for 120h; Sealed tube; Inert atmosphere; enantioselective reaction; | 98% |
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Chemistry
IUPAC Name:3-fluoro-4-methylaniline
Molecular Formula:C7H8FN
Molecular Weight:125.143523 g/mol
Melting Point:30-32 °C
Boiling Point:93°C 12mm
Flash Point:88 °C
density:1.093
refractive index:1.5385-1.5405
BRN:2715987
CAS DataBase Reference:452-77-7(CAS DataBase Reference)
Synonyms of 2-Fluoro-4-aminotoluene(452-77-7):
2-FLUORO-4-AMINO-TOLUENE;3-FLUORO-4-METHYLANILINE;3-FLUORO-4-METHYLBENZENEAMINE;3-FLUORO-P-TOLUIDINE;4-AMINO-2-FLUOROTOLUENE;3-fluoro-4-methyl-benzenamin;3-fluoro-p-toluidin;3-Fluoro-4-methylaniline 98%
Categories of 2-Fluoro-4-aminotoluene(452-77-7):
Fluorobenzene;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Miscellaneous;Anilines, Amides & Amines;Fluorine Compounds
Safety Profile
Safety Information of 2-Fluoro-4-aminotoluene(452-77-7):
Hazard Codes:T 
,Xi,Xn 
Risk Statements:36/37/38-23/24/25-20/21/22
36/37/38:Irritating to eyes, respiratory system and skin
23/24/25:Toxic by inhalation, in contact with skin and if swallowed
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:45-36/37/39-26-36/37-36
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37:Wear suitable protective clothing and gloves
36:Wear suitable protective clothing
RIDADR:2811
RTECS:XU6825000
Hazard Note:Toxic/Irritant
HazardClass:6.1(b)
PackingGroup:I
Specification
First Aid Measures of 2-Fluoro-4-aminotoluene(452-77-7):
Skin:Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
Storage of 2-Fluoro-4-aminotoluene(452-77-7):
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.